3399-67-5

Usage

Uses

Used in Chemical Derivatization:
(2-Aminoethyl)trimethylammonium chloride hydrochloride is used as a 'fixed charge' chemical derivatization reagent for structurally modifying peptides and polymers. This modification enhances the properties of these molecules, such as solubility, stability, and reactivity, which can be beneficial in various applications, including pharmaceuticals, materials science, and biotechnology.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, AETMA is used as a cationic agent to improve the delivery and targeting of drugs. Its cationic nature allows it to interact with negatively charged biological membranes, facilitating the transport of drugs across cell membranes and potentially enhancing their therapeutic effects.
Used in Materials Science:
In materials science, AETMA can be used to modify polymers and other materials to enhance their properties, such as conductivity, mechanical strength, and responsiveness to environmental stimuli. This can lead to the development of novel materials with improved performance in various applications, including sensors, actuators, and energy storage devices.
Used in Biotechnology:
In biotechnology, AETMA can be employed to modify biomolecules, such as proteins and nucleic acids, to improve their stability, solubility, and functionality. This can be particularly useful in the development of new biotechnological products, such as enzymes, biosensors, and therapeutic agents.

Purification Methods

Crystallise the hydrochloride from EtOH. The material is very soluble in H2O. [Beilstein 4 II 690.]

InChI:InChI=1/C5H15N2.ClH/c1-7(2,3)5-4-6;/h4-6H2,1-3H3;1H/q+1;/p-1

Upstream product

• 870-24-6 2-chloroethanamine hydrochloride 
• 75-50-3 trimethylamine 

Downstream Products

• 771577-04-9 {N-[3-(6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-yl)-phenyl]-N'-(ethyl-2-trimethyl-ammonium)}-urea-chloride hydrochloride 
• 1423219-07-1 2-(3-(3,5-bis(trifluoromethyl)phenyl)thioureido)-N,N,N-trimethylethanaminium 
• 1613619-40-1 (2-{5-cyano-2-[6-methoxycarbonyl-7-methyl-3-oxo-8-(3-trifluoromethyl-phenyl)-2,3,5,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrimidin-5-yl]-benzoylamino}-ethyl)-trimethyl-ammonium chloride 
• 1363334-40-0 C₂₂H₃₄N₃O₄⁽¹⁺⁾*Cl^(1-) 
• 1363334-43-3 C₂₆H₄₂N₃O₆⁽¹⁺⁾*Cl^(1-) 
• 1311370-96-3 2-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzamido)-N,N,N-trimethylethanaminium chloride 

Relevant academic research and scientific papers

Relative quantification of carboxylic acid metabolites by liquid chromatography-mass spectrometry using isotopic variants of cholamine

Labeling reagents that differ only in their isotopic composition offer a powerful approach to achieve relative quantification between samples by ESI-MS. Heavy and light isotopic forms of cholamine, which contain a positively charged quaternary ammonium group, were synthesized and tested as new labeling reagents for the relative quantification of carboxylic acid-containing metabolites, specifically fatty acids. The positive charge on cholamine ensures that the labeled product is also positively charged under all LC-MS conditions, regardless of mobile-phase pH. This leads to high ionization efficiency and correspondingly high detection sensitivity, demonstrated here for the analysis of fatty acids in positive ion mode ESI-MS after reversed-phase separation under acidic conditions. Good accuracy and precision were obtained by mixing heavy- and light-labeled hydrolyzed egg lipid extracts in different known ratios. The relative quantification results for 10 observed fatty acids had an average absolute error of 4.6% and an average coefficient of variation (CV) of 2.6%. The labeling strategy yielded a median CV of 6% when employed for fatty acid analysis of eggs from chickens fed various dietary supplements.

A Three-Dimensional Lead Halide Perovskite-Related Ferroelectric

Three-dimensional (3D) organic-inorganic lead halides represented by [CH3NH3]PbI3 perovskite have attracted great interest for their diverse functional properties and promising optoelectronic applications. However, 3D lead halides are still very rare and their ferroelectricity remains controversial. Here, we report an unprecedented 3D lead halide perovskite-related ferroelectric [2-trimethylammonioethylammonium]Pb2Cl6 ([TMAEA]Pb2Cl6), which contains a 3D lead chloride framework of corner- A nd edge-sharing PbCl6 octahedral, with the [TMAEA]+ cations occupying the voids of the framework. [TMAEA]Pb2Cl6 shows a ferroelectric-to-paraelectric phase transition with the Curie temperature as high as 412 K, a typical ferroelectric hysteresis loop at 293 K with a spontaneous polarization of 1 μC/cm2, and a clear ferroelectric domain switching. To the best of our knowledge, [TMAEA]Pb2Cl6 is the first 3D lead halide showing such an excellent ferroelectricity. Additionally, it also exhibits a semiconducting property with a direct band gap of 3.43 eV. This finding enriches the family of 3D hybrid lead halides and inspires the exploration of 3D lead halide ferroelectrics.

Ionizable isotopic labeling reagents for relative quantification by mass spectrometry

Relative quantification of metabolites by Electrospray Ionization Mass Spectrometry (ESI-MS) requiring a mechanism for simultaneous analysis of multiple analytes in two or more samples. Labeling reagents that are reactive to particular compound classes and differ only in their isotopic kit facilitating relative quantification and providing tangible evidence for the existence of specific functional groups. Heavy and light isotopic forms of methylacetimidate were synthesized and used as labeling reagents for quantification of amine-containing molecules, such as biological samples. Heavy and light isotopic forms of formaldehyde and cholamine were also synthesized and used independently as labeling reagents for quantification of amine-containing and carboxylic acid-containing molecules, such as found in biological samples. Advantageously, the labeled end-products are positively charged under normal acidic conditions involving conventional Liquid Chromatography Mass Spectrometry (LC/MS) applications. Labeled primary and secondary amine and carboxylic acid end-products also generated higher signals concerning mass-spectra than pre-cursor molecules and improved sensitivity. Improved accuracy concerning relative quantification was achieved by mixing heavy and light labeled Arabidopsis extracts in different ratios. Labeling strategy was further employed to ascertain differences in the amounts of amine-containing metabolites for two strains of Arabidopsis seeds.

POLYBASIC BACTERIAL EFFLUX PUMP INHIBITORS AND THERAPEUTIC USES THEREOF

Disclosed are compounds having polybasic functionalities. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.