33998-26-4

Usage

Uses

Used in Pharmaceutical Industry:
Cholesterol phenylacetate is used as a synthetic intermediate for the production of various pharmaceuticals and organic compounds. Its unique structure and properties make it a valuable component in the synthesis of new drugs and therapeutic agents.
Used in Liver Disease Treatment:
Cholesterol phenylacetate is being studied for its potential use in the treatment of liver disease. Its antioxidant and anti-inflammatory properties may contribute to the amelioration of liver conditions, although more research is needed to confirm its efficacy and safety in this application.
Used in Diagnostic and Monitoring Applications:
Cholesterol phenylacetate has been investigated as a potential marker for the diagnosis and monitoring of certain diseases. Its presence or levels in biological samples may provide valuable information about disease progression or response to treatment, aiding in the development of personalized medicine approaches.
Used in Antioxidant and Anti-Inflammatory Therapies:
Due to its antioxidant and anti-inflammatory properties, cholesterol phenylacetate may be useful in the development of novel therapies for various medical conditions. Its ability to modulate immune responses and reduce oxidative stress could contribute to the treatment of inflammatory and oxidative stress-related disorders.

InChI:InChI=1/C35H52O2/c1-24(2)10-9-11-25(3)30-16-17-31-29-15-14-27-23-28(37-33(36)22-26-12-7-6-8-13-26)18-20-34(27,4)32(29)19-21-35(30,31)5/h6-8,12-14,24-25,28-32H,9-11,15-23H2,1-5H3/t25-,28+,29+,30-,31+,32+,34+,35-/m1/s1

Upstream product

• 103-82-2 phenylacetic acid 
• 57-88-5 cholesterol 
• 103-80-0 phenylacetyl chloride 
• 57-88-5 cholesterol 
• 75178-11-9 Phenyl-acetic acid [2,2']bipyridinyl-6-yl ester 

Downstream Products

• 385449-60-5 5-cholesten-3β-yl phenyldiazoacetate 

Relevant academic research and scientific papers

Kinetic Analysis as an Optimization Tool for Catalytic Esterification with a Moisture-Tolerant Zirconium Complex

This work describes the use of kinetics as a tool for rational optimization of an esterification process with down to equimolar ratios of reagents using a recyclable commercially available zirconocene complex in catalytic amounts. In contrast to previously reported group IV metal-catalyzed esterification protocols, the work presented herein circumvents the use of water scavengers and perfluorooctane sulfonate (PFOS) ligands. Insights into the operating mechanism are presented.

High selectivity from configurational match/mismatch in carbon-hydrogen insertion reactions of steroidal diazoacetates catalyzed by chiral dirhodium(II) carboxamidates

Diazo decomposition of steroidal diazoacetates, where the point of attachment is the 3-position of the steroid A-ring, catalyzed by chiral dirhodium(II) carboxamidates results in products from carbon-hydrogen insertion in high yield and selectivities. Use of S-configured catalysts shows a distinctive preference for insertion into the 3-position to form β-lactone products. The R-configured catalysts direct insertion preferentially to the equatorial C-H bond at the 2-position. Substituents or functional groups at the 5/6-position prevent C-H insertion from taking place at the 4-position. Even in the best case with the 5/6-positions fully saturated, however, insertion into the 3-position remains competitive with insertion into the 4-position. Corresponding 3-substituted phenyldiazoacetates give only β-lactone products, and selectivity here is highest with chiral dirhodium(II) prolinate catalysts. A model is presented to explain these results. Overall, this methodology is versatile for functionalization of the steroid A-ring at positions 2 and 3.

A USEFUL METHOD FOR SELECTIVE ACYLATION OF ALCOHOLS USING 2,2'-BIPYRIDYL-6-YL CARBOXYLATE AND CESIUM FLUORIDE

Primary and secondary alcohols are acylated under mild conditions by the of use 2,2'-bipyridyl-6-yl carboxylates and cesium fluoride.Furthermore, the reaction is successfully applied to selective acylation of a primary carbinol group of diols containing primary and secondary carbinol groups or exclusive O-acylation of aromatic amino alcohols.