3400-05-3Relevant academic research and scientific papers
Catalytic Asymmetric Electrochemical α-Arylation of Cyclic β-Ketocarbonyls with Anodic Benzyne Intermediates
Fu, Niankai,Li, Longji,Li, Yao,Luo, Sanzhong,Zhang, Long
, p. 14347 - 14351 (2020)
Asymmetric catalysis with benzyne remains elusive because of the highly fleeting and nonpolar nature of benzyne intermediates. Reported herein is an electrochemical approach for the oxidative generation of benzynes (cyclohexyne) and its successful merging with chiral primary aminocatalysis, formulating the first catalytic asymmetric enamine–benzyne (cyclohexyne) coupling reaction. Cobalt acetate was identified to stabilize the in situ generated arynes and facilitate its coupling with an enamine. This catalytic enamine-benzyne protocol provides a concise method for the construction of diverse α-aryl (α-cyclohexenyl) quaternary carbon stereogenic centers with good stereoselectivities.
1-Arylsulfonylamino-1,2,3-triazole Derivatives from Functionalyzed 1,2-Cyclohexanediones
Benedetti, F.,Bozzini, S.,Forchiassin, M.,Nardin, G.,Pitacco, G.,et al.
, p. 301 - 305 (2007/10/02)
The heterocyclization reaction of arylsulfonylhydrazones from alkyl substituted 1,2-cyclohexanediones is sensitive to the steric requirements of the alkyl groups.A mechanism for the cyclization in acidic medium is also reported.
