340034-03-9Relevant academic research and scientific papers
The first bismuth(III)-catalyzed guanylation of thioureas
Cunha, Silvio,Rodrigues Jr., Manoel T.
, p. 6955 - 6956 (2006)
This work describes the first catalytic bismuth-promoted synthesis of polysubstituted guanidines in good yields through the guanylation reaction of N-benzoyl or N-phenylthioureas with primary and secondary amines, but now employing equimolar amounts of ea
Study of N-benzoyl-activation in the HgCl2-promoted guanylation reaction of thioureas. Synthesis and structural analysis of N-benzoyl-guanidines
Cunha, Silvio,Costa, Maísa B,Napolitano, Hamilton B,Lariucci, Carlito,Vencato, Ivo
, p. 1671 - 1675 (2001)
In this work, it is demonstrated that the benzoyl group is an activating group for thioureas in the HgCl2-guanylation reaction. Thus N-benzoyl-thioureas containing electronically neutral and even electron-withdrawing or electron-releasing subst
Bismuth nitrate pentahydrate: A new and environmentally benign reagent for guanidylation of N-benzoylthioureas
Cunha, Silvio,De Lima, Byanka R,De Souza, Aparecido R
, p. 49 - 52 (2002)
The bismuth nitrate-mediated guanidylation of N-benzoylthioureas was studied. This salt proved to be an effective guanylating reagent and allowed the obtention of N-benzoyl-guanidines in good yields. The methodology described is a promising alternative to the use of toxic HgCl2 in the synthesis of polysubstituted guanidines.
Iron Trichloride and Air Mediated Guanylation of Acylthioureas. An Ecological Route to Acylguanidines: Scope and Mechanistic Insights
Pape, Simon,Wessig, Pablo,Brunner, Heiko
, p. 4701 - 4712 (2016/07/06)
Recently we introduced iron trichloride as an environmentally benign and cost-efficient reagent for the synthesis of N-benzoylguanidines. This highly attractive synthetic approach grants access to a broad spectrum of N-benzoylguanidines under mild conditi
