34008-87-2

Basic information

• Product Name: 1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one
• Synonyms: 1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one
• CAS NO: 34008-87-2
• Molecular Weight: 268.272
• Mol File: 34008-87-2.mol
• Article Data: 22

Chemical Properties

• CAS DataBase Reference: 1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one(34008-87-2)
• EPA Substance Registry System: 1-(4-aminophenyl)-3-(4-nitrophenyl)prop-2-en-1-one(34008-87-2)

Safety Data

• Hazardous Substances Data: 34008-87-2(Hazardous Substances Data)

Upstream product

• 556-18-3 4-aminobenzaldehyde 
• 3156-41-0 1-nitro-4-[(E)-2-nitroeth-1-enyl]benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 99-92-3 p-aminobenzophenone 

Downstream Products

• 25870-91-1 1-(4-isothiocyanatophenyl)-3-(4-nitrophenyl)-2-propen-1-one 
• 1202546-45-9 1-acetyl-3-(4-aminophenyl)-5-(4-nitrophenyl)-2-pyrazoline 

Relevant articles and documents

Design, synthesis, and evaluation of different scaffold derivatives against NS2B-NS3 protease of dengue virus

The number of deaths or critical health issues is a threat in the infection caused by Dengue virus, which complicates the situation, as only symptomatic treatment is the current solution. In this regard we have targeted the dengue protease NS2B-NS3 that is responsible for the replication. The series was designed with the help of molecular modeling approach using docking protocols. The series comprised of different scaffolds viz. cinnamic acid analogs (CA1–CA11), chalcone (C1–C10) and their molecular hybrids (Lik1–Lik10), analogs of benzimidazole (BZ1-BZ5), mercaptobenzimidazole (BS1-BS4), and phenylsulfanylmethylbenzimidazole (PS1-PS4). Virtual screening of various natural phytoconstituents was employed to determine the interactions of designed analogs with the residues of catalytic triad in the active site of NS2B-NS3. We have further synthesized the selected leads. The synthesized analogs were evaluated for the cytotoxicity and NS2B-NS3 protease inhibition activity and compared with known anti-dengue natural phytoconstituent quercetin as the standard. CA2, BZ1, and BS2 were found to be more potent and efficacious than the standard quercetin as evident from the protease inhibition assay.

Synthesis and antiproliferative activity of chalcone-imide derivatives based on 3,4-dichloro-1h-pyrrole-2,5-dione

A series of chalcone imide derivatives,4'-aminochalcones-based dichloromaleimides,was synthesized from the reaction of 1-(4-acetylphenyl)-3,4-dichloro-1H-pyrrole-2,5-dione with various substituted aldehydes, or by treating 4'- aminochalcone with 3,4-dichlorofuran-2,5-dione in an alternative path. The structures of chalcone imide derivatives were established using IR, 1H NMR, 13C NMR, and mass spectroscopy. Antiproliferative effects of the newly synthesized compounds have been screened on two human cancer types via the MTT assay. Compounds with p-tolyl-1H-pyrrole-2,5-dione, and 4- bromophenyl-1H-pyrrole-2,5-dione derivatives, are highly active on the human liver cancer (HepG-2).On the other hand, all compounds were found to be more effective against breast cancer cells (MCF-7)than the positive control doxorubicin. The results of this work provide a basis for further research of selected chalcone-imide moiety as antiproliferative agents.

Synthesis, characterization and molecular docking of 1,2,4-triazole derivatives as potential antimicrobial agents

In this study, a new series of (E)-N-(4-(3-(3,5-dialkylphenyl)acryloyl)phenyl)-2-(1H-1,2,4-triazol-1-yl)acetamide (32-41) was synthesized, characterized by FT-IR, 1H NMR, 13C NMR and Mass spectral analysis and evaluated for their in