340127-55-1

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 331720-33-3 3,5-bis(tert-butyldimethylsilyloxy)benzoic acid tert-butyldimethylsilyl ester 
• 158139-68-5 3,5-bis-(tert-butyldimethylsilanyloxy)-benzoic acid 

Downstream Products

• 1453904-53-4 3,5-dihydroxy-N-(naphthalen-2-yl)benzamide 
• 350035-63-1 (6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl-4-yl)-methanol 
• 350035-64-2 4-bromomethyl-6-butoxy-3',5'-bis-(3-butoxy-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-benzyloxy)-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-biphenyl 
• 350035-52-8 (3,5-bis((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 181225-39-8 ((5-bromo-1,3-phenylene)bis(oxy))bis(tert-butyldimethylsilane) 

Relevant academic research and scientific papers

Cell sugar transport channel inhibitor

The invention discloses a cell sugar transport channel inhibitor of which the structure is shown as a formula (I). The cell sugar transport channel inhibitor disclosed by the invention can target a cell sugar transport channel, and inhibit tumor cell prol

Tumor diagnosis and treatment fluorescent probe for targeting tumor Wolburg effect

The invention discloses a tumor diagnosis and treatment fluorescent probe for targeting tumor Warburg effect, and the structure of the fluorescent probe is shown as a formula (I). The fluorescent probe can be directly used in a cell line to analyze and detect the expression degree of tumor cell GLUT1 protein, so as to complete the screening of tumor cells. Meanwhile, tumor cell proliferation is inhibited by directly blocking the GLUT1 channel to inhibit intake of sugar nutritional ingredients by tumors. And an effective means and a useful tool are provided for early screening and diagnosis oftumors, development of new anti-tumor drugs and the like.

Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2

Resveratrol (3,5,4′-trihydroxylstilbene) has been proposed to elicit a variety of positive health effects including protection against cancer and cardiovascular disease. The highest affinity target of resveratrol identified so far is the oxidoreductase enzyme quinone reductase 2 (QR2), which is believed to function in metabolic reduction and detoxification processes; however, evidence exists linking QR2 to the metabolic activation of quinones, which can lead to cell toxicity. Therefore, inhibition of QR2 by resveratrol may protect cells against reactive intermediates and eventually cancer. With the aim of identifying novel inhibitors of QR2, we designed, synthesized, and tested two generations of resveratrol analogue libraries for inhibition of QR2. In addition, X-ray crystal structures of six of the resveratrol analogues in the active site of QR2 were determined. Several novel inhibitors of QR2 were successfully identified as well as a compound that inhibits QR2 with a novel binding orientation.

Linear-dendritic poly(ester)-block-poly(ether)-block-poly(ester) ABA copolymers constructed by a divergent growth method

The divergent synthesis of amphiphilic linear-dendritic block copolymers, LDBCs, that contain linear poly(ethylene glycol), PEG, and dendritic poly(benzyl ester)s is explored in this report. First [G1]- and second [G2]-generation LDBCs are constructed fro

Toward globular macromolecules with functionalized interiors: Design and synthesis of dendrons with an interesting twist

(formula presented) Design and synthesis of a novel class of monodendrons, in which the functional units can potentially be directed toward the concave interiors of dendrimers, are described. The key feature of the design is the placement of the amphiphil