340142-53-2Relevant academic research and scientific papers
D-A-D fluorogenic probe for the rapid imaging of amyloid β plaques in?vivo
Yang, Hao-Yu,Zhang, Jing-Jing,Zang, Yi,Zhang, Hai-Yan,Li, Jia,Chen, Guo-Rong,He, Xiao-Peng
, p. 224 - 228 (2016/09/04)
The effective imaging of amyloid β (Aβ) in?vivo is important for the diagnosis of Aβ-related diseases such as the Alzheimer's disease (AD). Here we report a donor-acceptor-donor (D-A-D) type fluorogenic probe for the rapid imaging of amyloid β (Aβ) senile plaques in a transgenic mouse brain. The probe that features a dicyanomethylene-4H-pyran (DCM) core shows a concentration-dependent fluorescence enhancement with Aβ42 and Aβ40, which are the main components of Aβ fibrils formed in the brain of AD patients. The D-A-D probe can also be used to rapidly sense Aβ peptide monomer, oligomer and fibril in an aqueous solution and image the morphologically diverse Aβ species by confocal microscopy. In particular, we demonstrate that the probe can be used to rapidly stain Aβ senile plaques in the brain of transgenic mice by intravenous injection.
Preparation of 4-dicyanomethylene-2,6-distyryl-4H-pyran derivatives, their functional polystyrenes and study of their different aggregation induced emission behaviors
Zhang, You-Hao,Gu, Pei-Yang,Zhou, Jie-Bo,Xu, Yu-Jie,Liu, Wu,Gu, Qian-Feng,Chen, Dong-Yun,Li, Na-Jun,Xu, Qing-Feng,Lu, Jian-Mei
, p. 2082 - 2088 (2014/03/21)
Aggregated or solid state red fluorescent materials with efficient light emission are rare but have wide applications in optoelectronic and biological fields. Herein, two pyran derivatives, EtAmPy and EtOxPy with different charge transfers (CT), were designed as initiators and introduced to polystyrene chains via atom transfer radical polymerization (ATRP). The emission of EtAmPy was quenched both in highly polar solvents and in an aggregated state because of its strong CT and intermolecular interactions, respectively. After EtAmPy was introduced to normal polystyrene chains, the obtained functional PS emitted strong red light with a quantum yield of 37% in an aggregated state. Differently from EtAmPy, EtOxPy, possessing a weak CT and not being sensitive to the change of microenvironment, was AIE-active and displayed a large red shift in emission spectra in an aggregated state. Meanwhile, the functional PS initiated by EtOxPy showed obviously blue-shifted emission, compared to its initiator, in an aggregated state by reducing their intermolecular interactions. EtAmPy-functionalized polystyrene showed a successful application in cell imaging. Therefore, using the CT effect in molecular design and polymerization is beneficial to obtaining new red emission probes. The Royal Society of Chemistry.
