340267-69-8

Upstream product

• 866336-05-2 3-(4-methanesulfinyl-phenyl)-4-phenyl-5-trifluoromethyl-isoxazole 
• 866336-06-3 thiobutyric acid S-[4-(4-phenyl-5-trifluoromethyl-isoxazol-3-yl)-phenyl] ester 
• 74-88-4 methyl iodide 

Downstream Products

• 340267-36-9 3-(4-methylsulphonylphenyl)-4-phenyl-5-trifluoromethylisoxazol 
• 866336-05-2 3-(4-methanesulfinyl-phenyl)-4-phenyl-5-trifluoromethyl-isoxazole 

Relevant academic research and scientific papers

RADIOLABELED ARYLSULFONYL COMPOUNDS AND USES THEREOF

The present invention relates to Radiolabeled Arylsulfonyl Compounds and methods of use thereof as imaging agents for the COX-2 enzyme using positron-emission tomograpy (PET). Methods of making the Radiolabeled Arylsulfonyl Compounds and pharmaceutical co

A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression

A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled methylsulfone group. The potential of this methodology has been demonstrated by the successful radiosynthesis of carbon-11 analogues of several highly selective cyclooxygenase-2 (COX-2) inhibitors such as Rofecoxib, Etoricoxib, and 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethyl isoxazole in high yield. The chemical and radiochemical purities obtained for the 11C-labeled COX-2 inhibitors are >99% with a specific activity >1000 Ci/mmol.