866336-06-3Relevant academic research and scientific papers
A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression
Majo, Vattoly J.,Prabhakaran, Jaya,Simpson, Norman R.,Van Heertum, Ronald L.,Mann, J. John,Kumar, J. S. Dileep
, p. 4268 - 4271 (2007/10/03)
A general one-pot method has been developed for the conversion of an aryl thiol moiety masked as the butyrate ester to the corresponding 11C-labeled methylsulfone group. The potential of this methodology has been demonstrated by the successful radiosynthesis of carbon-11 analogues of several highly selective cyclooxygenase-2 (COX-2) inhibitors such as Rofecoxib, Etoricoxib, and 3-(4-methylsulfonylphenyl)-4-phenyl-5-trifluoromethyl isoxazole in high yield. The chemical and radiochemical purities obtained for the 11C-labeled COX-2 inhibitors are >99% with a specific activity >1000 Ci/mmol.
RADIOLABELED ARYLSULFONYL COMPOUNDS AND USES THEREOF
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Page/Page column 32; 33-34, (2008/06/13)
The present invention relates to Radiolabeled Arylsulfonyl Compounds and methods of use thereof as imaging agents for the COX-2 enzyme using positron-emission tomograpy (PET). Methods of making the Radiolabeled Arylsulfonyl Compounds and pharmaceutical co
