340270-78-2

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 34290-59-0 (S)-methyl 2-((2S)-2-[(tert-butoxycarbonyl)-3-phenylpropanamido]-3-hydroxy)-propanoate 
• 189459-10-7 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester 

Downstream Products

• 142342-82-3 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester 
• 132402-66-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonyl-(R)-Δ2-thiazoline 
• 340270-76-0 C₄₉H₇₄Cl₃N₇O₁₂S 
• 340270-79-3 C₄₉H₇₂Cl₃N₇O₁₁S 
• 340270-75-9 2-(2-{[1-(2-{2-[3-(1,1-dimethyl-allyloxy)-2-(2,2,2-trichloro-1,1-dimethyl-ethoxycarbonylamino)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester 
• 564489-36-7 (S)-2-((S)-2-{[(S)-1-((S)-2-{(2S,3S)-2-[(S)-2-Amino-3-(1,1-dimethyl-allyloxy)-propionylamino]-3-methyl-pentanoylamino}-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester 
• 340270-74-8 (S)-2-[(S)-2-({(S)-1-[(S)-2-((2S,3S)-2-tert-Butoxycarbonylamino-3-methyl-pentanoylamino)-propionyl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-thiopropionylamino]-3-hydroxy-propionic acid methyl ester 
• 340270-73-7 (S)-2-((S)-2-{[(S)-1-((S)-2-tert-Butoxycarbonylamino-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester 
• 340270-72-6 (S)-2-[(S)-1-((S)-2-Hydroxy-1-methoxycarbonyl-ethylthiocarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Total synthesis of trunkamide A, a novel thiazoline-based prenylated cyclopeptide metabolite from Lissoclinum sp.

Full details of a total synthesis of the doubly prenylated cyclic peptide trunkamide A of marine origin, and also its C45 epimer, are described.

Total synthesis of the prenylated cyclopeptide trunkamide A, a cytotoxic metabolite from Lissoclinum sp.

A total synthesis of the doubly prenylated cyclic peptide trunkamide A of marine origin, and also its C45 epimer, is described.

Synthesis of peptidyl aldehydes from thiazolidines

Peptidyl aldehydes were synthesized using thiazolidine peptides as precursors. Hydrolysis of the heterocycles is easily accomplished using cupper salts to furnish the peptidyl aldehydes with very good yield and with no epimerization.