132402-66-5

Upstream product

• 18598-63-5 L-cysteine methyl ester hydrochloride 
• 132402-59-6 2(S)--3-phenylpropanimino ethyl ether 
• 142342-82-3 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-hydroxy-propionic acid methyl ester 
• 940950-77-6 C₁₈H₂₄N₄O₅S 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 189459-10-7 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester 
• 340270-78-2 (S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-thiopropionylamino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester 
• 88463-18-7 (S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide 

Downstream Products

• 132402-81-4 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-carboxythiazole 
• 132402-74-5 2-<(S)-1-t-butyloxycarbonylamino-2-phenyl-ethyl>-4-methoxycarbonylthiazole 

Relevant academic research and scientific papers

Peptide-embedded heterocycles by mild single and multiple aza-Wittig ring closures

Ring a ring o'azoles: The aza-Wittig cyclization of amino acids and peptides is extremely mild, selective, and versatile. The reaction of amino acid esters and amino acid thioester azides delivers peptidic 1,3-azolines and 1,3-azoles with unsurpassed func

Synthesis of peptidyl aldehydes from thiazolidines

Peptidyl aldehydes were synthesized using thiazolidine peptides as precursors. Hydrolysis of the heterocycles is easily accomplished using cupper salts to furnish the peptidyl aldehydes with very good yield and with no epimerization.

Formation of oxazolines and thiazolines in peptides by the Mitsunobu reaction

The Mitsunobu reaction was efficiently used to introduce oxazolines and thiazolines in the peptide backbone. The reaction proceeded from β-hydroxy α-amino acid-containing peptides at room temperature in 58-72% isolated yields.

Synthetic studies towards cyclic peptides. Concise synthesis of thiazoline and thiazole containing amino acids

Concise and efficient syntheses of optically pure thiazoline and thiazole containing amino acids of the constitution (26) and (27), based on simple condensation reactions between cysteine esters and N-protected imino ethers (22) and (25) derived from chir