3403-82-5Relevant academic research and scientific papers
FUNCTIONALIZED LONG-CHAIN HYDROCARBON MONO- AND DI-CARBOXYLIC ACIDS AND THEIR USE FOR THE PREVENTION OR TREATMENT OF DISEASE
-
Paragraph 0541-0543, (2021/01/29)
This invention provides compounds of Formulae (IA), (IB), (IC), (ID), (IE), (IF), (IG), (IH), (IJ), (IK), (IL), (II), (III), (IIIA), and (IIIB); pharmaceutically acceptable salts and solvates thereof; and compositions thereof. This invention further provides methods for treating a disease, including but not limited to, liver disease or an abnormal liver condition; cancer (such as hepatocellular carcinoma or cholangiocarcinoma); a malignant or benign tumor of the lung, liver, gall bladder, bile duct or digestive tract; an intra- or extra-hepatic bile duct disease; a disorder of lipoprotein; a lipid-and-metabolic disorder; cirrhosis; fibrosis; a disorder of glucose metabolism; a cardiovascular or related vascular disorder; a disease resulting from steatosis, fibrosis, or cirrhosis; a disease associated with increased inflammation (such as hepatic inflammation or pulmonary inflammation); hepatocyte ballooning; a peroxisome proliferator activated receptor-associated disorder; an ATP citrate lyase disorder; an acetyl-coenzyme A carboxylase disorder; obesity; pancreatitis; or renal disease.
Synthesis method of 5-oxa-nonanedioic acid
-
Paragraph 0005; 0010, (2020/01/25)
The invention relates to a synthesis method of 5-oxa-nonanedioic acid, and mainly solves the technical problem of lack of effective synthesis methods of 5-oxa-nonanedioic acid. The synthesis method provided by the invention comprises the following steps: under protection of nitrogen, adding 4-bromobutyl benzyl ether into a dimethylsulfoxide (DMSO) solution of 1,4-butanediol and potassium hydroxideto generate a compound 1; carrying out catalytic debenzylation on the compound 1 by Pd/C in methanol in a hydrogen environment to generate a compound 2; and oxidizing the compound 2 by a Jones reagent in acetone to produce a target compound 3. The reaction formula is as follows. The synthesis method has the advantages of short reaction time, mild reaction, high product purity and high yield.
TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE
-
Paragraph 1166, (2018/05/24)
The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.
Steroidal bivalent ligands for the estrogen receptor: Design, synthesis, characterization and binding affinities
LaFrate, Andrew L.,Carlson, Kathryn E.,Katzenellenbogen, John A.
supporting information; experimental part, p. 3528 - 3535 (2009/10/17)
Steroidal bivalent ligands for the estrogen receptor (ER) were designed using crystal structures of ERα dimers as a template. The syntheses of several 17α-ethynylestradiol-based bivalent ligands with varying linker compositions and lengths are described. The binding affinities of these bivalent ligands for ERα and ERβ were determined. In the two series of bivalent ligands that we synthesized, there is a clear correlation between linker length and binding affinity, both of which reach a maximum at the same tether length. Further studies are underway to explore aspects of bivalent ligand and control compound binding to the ERs and their effects on ER dimer formation; these results will be reported in a subsequent publication.
Preparation of 1,4-butanediol and tetrahydrofuran
-
, (2008/06/13)
Mixtures which contain 1,4-butanediol and tetrahydrofuran are prepared by heating 4-hydroxybutyraldehyde of the formula STR1 at 20°-300° C. in the presence or absence of 1,4-butanediol and subjecting the resulting acetals of the formulae STR2 to a catalytic hydrogenation at 50°-300° C. and 1-350 bar.
SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES OF AN IRON CATALYST. 2. THE CONVERSIONS OF 1,4-BUTANEDIOL AND DIETHYLENEGLYCOL IN THE PRESENCE OF AMMONIA AND HYDROGEN
Kliger, G. A.,Lesik, O. A.,Marchevskaya, E. V.,Mikaya, A. I.,Zaikin, V. G.,et al.
, p. 161 - 164 (2007/10/02)
The gas-phase interaction of 1,4-butanediol and diethylene glycol with ammonia and/or hydrogen on a reduced, fused, iron catalyst has been investigated.
Aliphatic and cyclic perfluoro-alkyl ethers and process for the preparation thereof
-
, (2008/06/13)
Mono- or polyhydric alcohols of the alkan-, tetrahydrofuran- or tetrahydropyran series or di- or tri-alkyleneglycols are dissolved in an aprotic polar solvent and reacted with C3 F6 in the presence of trialkylamines, or with tetrafluoroethylene to give the corresponding tetrafluoroethyl- or hexafluoropropyl ethers. The solution of the fluoroethers in anhydrous hydrofluoric acid is electrolyzed. Hydrogen-free perfluoroethers are obtained.
