34058-50-9

Usage

Uses

Used in Pharmaceutical and Medicinal Applications:
2-Methyl-1H-indole-4-carboxylic acid is utilized as a pharmaceutical intermediate for the development of new drugs. Its structural features allow it to serve as a building block in the synthesis of biologically active compounds, potentially leading to the discovery of novel therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Methyl-1H-indole-4-carboxylic acid is employed as a key component in the creation of new chemical entities. Its unique structure enables the design of compounds with tailored properties, which can be applied across various industries, including materials science, agrochemicals, and specialty chemicals.

Upstream product

• 6127-18-0 4-bromo-2-methyl-1H-indole 
• 359585-96-9 2-methyl-1H-indol-4-yl trifluoromethanesulfonate 
• 35320-67-3 4-hydroxy-2-methyl-1H-indole 
• 34058-51-0 methyl 2-methyl-1H-indole-4-carboxylate 

Downstream Products

• 208773-39-1 benzyl 2-methyl-1H-indole-4-carboxylate 
• 34058-51-0 methyl 2-methyl-1H-indole-4-carboxylate 
• 756478-92-9 benzyl [1-(4-butoxybenzoyl)-2-methyl-1H-indol-4-yl]acetate 
• 359586-03-1 benzyl 1-(4-butoxybenzoyl)-2-methyl-1H-indole-4-carboxylate 
• 359583-47-4 1-(4-butoxybenzoyl)-2-methyl-1H-indole-4-carboxylic acid 

Relevant academic research and scientific papers

AMINOACYLINDAZOLE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES

2-Acylindazole compounds of formula I or formula II are disclosed. These compounds inhibit Coagulation Factor XIIa. They are useful to treat autoimmune diseases.

Development of a prostaglandin D2 receptor antagonist: Discovery of a new chemical lead

A series of N-(p-alkoxy)benzoyl-5-methoxy-2-methylindole-3-acetic acids and N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid were discovered as new chemical leads for a prostaglandin D2 (PGD2) receptor antagonist. Most of them exhibi

Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.

The process of discovery for highly potent prostaglandin D(2) (PGD(2)) receptor antagonists is reported. A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and identified as a new class of selective PGD(2) receptor antagonists.

Discovery of new chemical leads for prostaglandin D2 receptor antagonists

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4- acetic acid 2 was discovered as a new chemical lead for a prostaglandin D 2 (PGD2) recept

INDOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT

Indole derivatives represented by formula (I) ???wherein all symbols represent the same as that in specification), production methods thereof, and DP receptor antagonist comprising them as active ingredients. Since the compounds of formula (I) binds and antagonizes to DP receptor, they are useful for the prevention and/or treatment against allergic diseases, diseases accompanied with itching, secondary diseases generated by behaviors caused by itching, inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis.

Indole derivatives, process for preparation of the same and use thereof

Indole derivatives represented by formula (I): (wherein all symbols are described in the description), a process for the preparation of the same and a DP receptor antagonist comprising it as an active ingredient. Since the compounds of formula (I) binds to and are antagonistic to a DP receptor, they are useful in for the prevention and/or treatment of diseases, for example, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma, food allergy, etc., systemic mastocytosis; disorders due to systemic mastocyte activation, anaphylactic shock, bronchoconstriction, urticaria, eczema, etc.), diseases accompanied with itching (atopic dermatitis, urticaria, etc.), secondary diseases caused by behaviors (scratching behaviors, beating, etc.) (cataract, retinal detachment, inflammation, infection, sleep disorder, etc.), inflammation, chronic obstructive pulmonary disease, ischemic reperfusion disorder, cerebrovascular disorder, pleuritis complicated by rheumatoid arthritis, ulcerative colitis, and the like.