756478-92-9

Upstream product

• 100-51-6 benzyl alcohol 
• 71-36-3 butan-1-ol 
• 359586-17-7 1-(4-hydroxybenzoyl)-2-methyl-1H-indol-4-yl acetic acid benzyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 35320-67-3 4-hydroxy-2-methyl-1H-indole 
• 359585-97-0 tert-butyl 2-methyl-4-{[(trifluoromethyl)sulfonyl]oxy}-1H-indole-1-carboxylate 
• 359585-98-1 tert-butyl 2-methyl-4-[(trimethylsilyl)ethynyl]-1H-indole-1-carboxylate 
• 359586-00-8 2-methylindole-4-acetic acid 
• 34058-51-0 methyl 2-methyl-1H-indole-4-carboxylate 
• 34058-50-9 2-methyl-1H-indole-4-carboxylic acid 
• 359585-99-2 1-tert-butoxycarbonyl-2-methyl-1H-indol-4-yl acetic acid 
• 359586-15-5 benzyl (2-methyl-1H-indol-4-yl)acetate 
• 359586-03-1 benzyl 1-(4-butoxybenzoyl)-2-methyl-1H-indole-4-carboxylate 
• 359583-47-4 1-(4-butoxybenzoyl)-2-methyl-1H-indole-4-carboxylic acid 

Relevant academic research and scientific papers

Development of a prostaglandin D2 receptor antagonist: Discovery of a new chemical lead

A series of N-(p-alkoxy)benzoyl-5-methoxy-2-methylindole-3-acetic acids and N-(p-butoxy)benzoyl-2-methylindole-4-acetic acid were discovered as new chemical leads for a prostaglandin D2 (PGD2) receptor antagonist. Most of them exhibi

Discovery of orally active prostaglandin D2 receptor antagonists

Discovery process of a new PGD2 receptor antagonists 3i is reported. A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and evaluated for prostaglandin D2 (DP) receptor affinity and antagonist activity. So

Discovery of new chemical leads for prostaglandin D2 receptor antagonists

A series of Indomethacin analogs were synthesized and biologically evaluated. Among the compounds tested, N-(p-butoxy)benzoyl-2-methylindole-4- acetic acid 2 was discovered as a new chemical lead for a prostaglandin D 2 (PGD2) recept

Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.

The process of discovery for highly potent prostaglandin D(2) (PGD(2)) receptor antagonists is reported. A series of N-(p-alkoxy)benzoyl-2-methylindole-4-acetic acids were synthesized and identified as a new class of selective PGD(2) receptor antagonists.