3406-36-8Relevant academic research and scientific papers
N -Monomethylation of amines using paraformaldehyde and H2
Wang, Hongli,Huang, Yongji,Dai, Xingchao,Shi, Feng
, p. 5542 - 5545 (2017)
The selective N-monomethylation of amines is an important topic in fine chemical synthesis. Herein, for the first time, we described a selective N-monomethylation reaction of amines with paraformaldehyde and H2 in the presence of a CuAlOx catalyst. A variety of amines, including primary aromatic amines, benzylamine and cyclohexylamine, as well as secondary amines, have been shown to be compatible with this reaction.
