34060-72-5

Basic information

• Product Name: Benzene, 4-chloro-2-(chloromethyl)-1-methyl-
• Synonyms: 4-chloro-2-chloromethyl-toluene;α-chloro-4-chloro-orthoxylene;α-Cl-4-COX;Chlor-methyl-chlormethylbenzol
• CAS NO: 34060-72-5
• Molecular Formula: C8H8Cl2
• Molecular Weight: 175.058
• Mol File: 34060-72-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 4-chloro-2-(chloromethyl)-1-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 4-chloro-2-(chloromethyl)-1-methyl-(34060-72-5)
• EPA Substance Registry System: Benzene, 4-chloro-2-(chloromethyl)-1-methyl-(34060-72-5)

Safety Data

• Hazardous Substances Data: 34060-72-5(Hazardous Substances Data)

Upstream product

• 58966-29-3 (5-chloro-2-methylphenyl)methanol 
• 7499-06-1 5-chloro-2-methylbenzoic acid 
• 95-47-6 o-xylene 
• 615-60-1 4-chloro-1,2-dimethylbenzene 

Downstream Products

• 95-47-6 o-xylene 
• 55676-84-1 2-benzyl-4-chloro-1-methylbenzene 

Relevant articles and documents

SUBSTITUTED DIHYDROISOQUINOLINONE COMPOUNDS

This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

SELECTIVITY AND MECHANISM IN THE SIDE-CHAIN HALOGENATION OF METHYLBENZENES PROMOTED PHOTOCHEMICALLY AND BY METAL COMPLEXES IN THE PRESENCE OF HALIDE IONS

The intramolecular selectivity in a variety of side-chain halogenations of alkyl-aromatics has been determined in AcOH by measuring the isomeric distribution in the reactions of 4-t-butyl- and 4-chloro-1,2-dimethylbenzene (1 and 2, respectively) with: Br2/hν, CAN/Br-, CAN=cerium(IV) ammonium nitrate, cobalt(III) acetate/Br-, S2O8=/Br-, N-bromosuccinimide (in CCl4), Cl2/hν, CAN/Cl-, cobalt(III) acetate/Cl-.In the bromination reactions selectivity is independent of the reaction conditions, thus suggesting that in all brominating systems Br. is the actual reacting species.Very surprisingly, with 1 as the substrate, Cl2/hν is a more selective system than Br2/hν.With 2 the two systems display similar selectivity.It has been suggested that in AcOH the transition state for photochlorination has an electron transfer character which increases as the substrate becomes more electron rich.The idea of a "variable" transition state for the photochlorination in AcOH is supported by data of relative reactivity of substituted toluenes indicating that the effect on the rate increases as the substituent becomes more electron donor.AcOH must have an essential role in this respect since in CCl4 situation returns to be "normal" with chlorination less selective than bromination.Selectivity of CAN/Cl- is very similar to that of Cl2/hν, whereas significant differences are observed with cobalt(III) acetate/Cl-.Probably Cl. and a cobalt(III) chloride complex are the reacting species in CAN/Cl- and cobalt(III) acetate/Cl-, respectively.