340728-91-8Relevant academic research and scientific papers
Synthesis of peptide-diazeniumdiolate conjugates: Towards enzyme activated antitumor agents
Tang, Xiaoping,Xian, Ming,Trikha, Mohit,Honn, Kenneth V.,Wang, Peng George
, p. 2625 - 2629 (2001)
The development of NO donors with site-specific and time-controlled properties is of great interest. We have designed a novel prodrug class as possible agents against metastatic prostate cancer by coupling a diazeniumdiolate to the terminal carboxyl groups of amino acids or peptides, such as Ser-Ser-Tyr-Tyr, Ser-Ser-Phe-Tyr, and Gly-Ile-Ser-Ser-Phe-Tyr. These prodrugs can be activated by α-chymotrypsin or prostate specific antigen and are potentially potent compounds for prostatic cancer.
