340819-80-9Relevant articles and documents
Synthesis of tritium labeled [3R-3H]-, and [3S-3H]-L-phenylalanine
Jemielity,Kanski,Kanska
, p. 295 - 304 (2001)
The synthesis of two selectively labeled isotopomers of L-phenylalanine, (Phe), using chemical and enzymatic methods is reported. The [3R-3H]-L-Phe isotopomer has been obtained from [3-3H]cinnamic acid prepared from benzaldehyde and malonic acid using tritiated water as a source of radioactive label, and by addition of ammonia in the presence of enzyme PAL. The [3S-3H]-L-Phe isotopomer has been synthesized by addition of ammonia to cinnamic acid in a buffered medium containing PAL and tritiated water.
Synthesis of tritium labeled isotopomers of L-tyrosine
Augustyniak,Suchecki,Jemielity,Kanski,Kanska
, p. 559 - 567 (2007/10/03)
The synthesis of four selectively labeled isotopomers of L-tyrosine, (L-Tyr), using chemical and enzymatic methods is reported. Four tritium labeled isotopomers of L-phenylalanine (L-Phe) - [2-3H]-, [2′,6′-3H2]-, [3R-3H]- and [3S-3H]- have been synthesized using a combination of chemical and enzymatic methods. The labeled isotopomers of L-Phe have been converted into [2-3H]-, [2′,6′-3H2]-, [3R-3H]-, and [3S-3H]-L-Tyr by using the enzyme L-phenyl-alanine 4′-monooxygenase. Copyright