340821-83-2Relevant academic research and scientific papers
A convenient synthesis of N-t-butyl-N′-aminocarbonyl-N-(substituted)benzoylhydrazine containing α-aminoalkylphosphonate groups in a one-pot procedure
Wang, Qingmin,Li, Zaiguo,Huang, Runqiu,Cheng, Junran
, p. 68 - 72 (2007/10/03)
A variety of novel N-t-butyl-N′-aminocarbonyl-N-(substituted)benzoylhydrazines containing α-aminoalkylphosphonate groups were synthesized. Treatment of α-aminoalkylphosphonates with triphosgene yielded α-isocyanatoalkylphosphonates, and subsequent addition with N-t-butyl-N-substituted benzoylhydrazines provided the title compounds in a one-pot procedure with good yields. The triphosgene-mediated reaction for the synthesis of α-isocyanatoalkylphosphonates enjoys a number of advantages: the reaction is carried out under mild condition in good yield, triphosgene is relatively safe to handle because of its low vapor pressure and high stability, and the experimental procedure is simple. This method can be applicable to the synthesis of other α-isocyanatoalkyl-phosphonates and urylenediphosphonates. The structures of all of the products and by-products were confirmed by 1H NMR, 31P NMR, IR and mass spectroscopy, and elemental analysis. We also found that some of the compounds possess potential anti-tobacco mosaic virus (TMV) activities and anticancer activities.
