99981-48-3

Upstream product

• 98-88-4 benzoyl chloride 
• 100875-33-0 benzoic acid-(tert-butyl-isopropylidene-hydrazide) 
• 170102-27-9 N-tert-butyl-N'-phenoxycarbonyl-N-benzoylhydrazine 
• 284044-47-9 N-t-butyl-N'-benzyloxycarbonyl-N-benzoylhydrazine 

Downstream Products

• 403739-88-8 C₁₈H₂₀ClN₃O₂ 
• 403739-80-0 C₂₀H₂₅N₃O₂ 
• 112225-87-3 benzoic acid N'-benzoyl-N-tert-butylhydrazide 
• 126632-86-8 N'-t-butyl-N-benzene-sulfonyl-N'-benzoylhydrazine 
• 129536-88-5 N'-t-butyl-N'-benzoyl-N-(1-cyano-1-methyl)ethylhydrazine 
• 112410-55-6 N-(3-toluoyl)-N'-t-butyl-N'-benzoylhydrazine 
• 129536-69-2 N'-t-butyl-N'-benzoyl-N-[N-(4-tolyl)aminocarbonyl]hydrazine 
• 403612-83-9 N-tert-butyl-N'-ferrocenoyl-N-benzoylhydrazine 

Relevant academic research and scientific papers

A Convenient Synthesis of Novel N′-tert-Butyl-N′-Substituted Benzoyl-N-(Substituted Phenyl)aminocarbonylhydrazines and Their Derivatives

N-tert-butyl-N-substituted benzoylhydrazines were prepared in two convenient procedures with good yields, subsequent reaction with substituted phenylisocyanates in 1,2-dichloroethane provided a series of novel N′-tert-butyl-N‰-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines. Further treatment with oxalyl chloride gave their derivatives in good yields. The title compounds exhibit moderate larvicidal activities and anticancer activities.

Alkylgermasesquioxide Derivatives of tert-Butyl-diacylhydrazines

N-tert-Butyl-N-benzoylhydrazine was synthesized by a new method. Its condensation and the condensation of its N,N'-isomer with 3-(trichlorogermyl)propionyl chloride provided N-tert-butyl-N'-(3-trichlorogermyl)propionyl-N-benzoylhydrazine or its N,N,N'-isomer, respectively, in good yields. Subsequent hydrolysis of the trichlorogermyl compounds using saturated sodium carbonate yielded the corresponding germasesquioxide derivatives that have good solubility in organic solvents. The structures of these compounds were confirmed by 1H NMR, IR, MS, and elemental analysis. The hydrolysis of organogermanium trichloride was studied, and the elimination of HGeCl3 was observed when the basicity was too high (pH>10).

New Reactions of N-t-Butyl-N-Benzohydrazine with Triphosgene

N-tert-Butyl-N-benzoylhydrazine was prepared in a new and convenient procedure with good yield. Triphosgene underwent reaction with three equivalents of N-t-butyl-N-benzoylhydrazine using six equivalents of triethylamine as a base to yield the cyclic tetramer of N-t-butyl-N-isocyanatobenzoylamide. Treatment of triphosgene with three equivalents of N-t-butyl-N-benzoylhydrazine either in the presence of three equivalents of triethylamine or in the absence of triethylamine afforded the cyclic pentamer of isocyanate, from which tert-butyl is eliminated.

Synthesis and biological activity of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives

Benzyl chloroformate was synthesised by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-tert-Butyl-N-substituted benzoylhydrazines were prepared in a new and convenient procedure with good yields. A series of novel N′-tert-butyl-N′-substituted benzoyl-N-(substituted phenyl)aminocarbonylhydrazines and their derivatives were synthesised and evaluated for molting hormone mimicking activity. The results of bioassays showed that the title compounds exhibit good larvicidal activities and toxicity assays indicated that the title compounds can induce a premature, abnormal and lethal larval molt. We have found that the title compounds possess potential anticancer activities.

Insecticidal N'-substituted-N,N'-disubstitutedhydrazines

This invention relates to N'-substituted-N,N'-disubstitutedhydrazines of formula I wherein X and X' are independently O, S, or NR; A' and B' are independently substituted or unsubstituted aryl or aromatic heterocycle; wherein F is alkyl, alkenyl, or aralkyl; and wherein E is a tertiary carbon containing organic radical having a total of at least four carbon and halogen atoms but not more than six halogen atoms, or a non-tertiary carbon containing non-haloalkyl organic or organometallic radical having at least five atoms other than hydrogen, oxygen and halogen which are useful as insecticides, compositions containing those compounds, methods of producing the compounds, and methods of their use. More particularly, the invention relates to insect growth regulating compounds and compositions, and methods of using such compounds and compositions. Compounds of the present invention are particularly suitable for controlling plant-destructive insects in crops of cultivated plants, ornamentals and forestry.

Condensation reaction of 1-oxo-4-chlorocarbonyl-1-phospha-2,6,7-trioxabicyclo[2.2.2]octane with N-t-butyl-N-benzoylhydrazine

1-Oxo-4-chlorocarbonyl-l-phospha-2,6,7-trioxabicyclo[2.2.2]octane (5) was obtained from phosphorus oxychloride. Benzyl chloroformate was synthesized by the reaction of benzyl alcohol and triphosgene in good yield for the first time. N-t-Butyl-N-benzoylhydrazine (11) was prepared in a new and convenivent procedure with good yield. The reaction of 5 and 11 proceeded smoothly in the presence of sodium carbonate and afforded the desired compound 13 in good yield, while in the presence of triethylamine, the elimination of butyl was observed and afforded the compound 12.

Six-membered heterocyclic derivatives of N'-substituted N,N'-diacylhydrazines

This invention relates to insecticidal compositions containing six-membered heterocyclic derivatives of N'-substituted-N,N'-diacylhydrazines, methods of using such compositions and novel six-membered heterocyclic derivatives of N'-substituted-N,N'-diacylhydrazines.