340825-20-9

Basic information

• Product Name: ethyl 2-(3-chloro-4-fluorophenyl)acetate
• Synonyms: ethyl 2-(3-chloro-4-fluorophenyl)acetate
• CAS NO: 340825-20-9
• Molecular Formula: C10H10ClFO2
• Molecular Weight: 216.6366032
• Mol File: 340825-20-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ethyl 2-(3-chloro-4-fluorophenyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(3-chloro-4-fluorophenyl)acetate(340825-20-9)
• EPA Substance Registry System: ethyl 2-(3-chloro-4-fluorophenyl)acetate(340825-20-9)

Safety Data

• Hazardous Substances Data: 340825-20-9(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(3-chloro-4-fluorophenyl)acetate is a chemical compound with the molecular formula C10H10ClFO2. It is a colorless to pale yellow liquid with a fruity odor. ethyl 2-(3-chloro-4-fluorophenyl)acetate is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in the production of perfumes and flavoring agents. Ethyl 2-(3-chloro-4-fluorophenyl)acetate is considered to be a potentially hazardous substance and should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 64-17-5 ethanol 
• 705-79-3 2-(3-chloro-4-fluorophenyl)acetic acid 

Relevant articles and documents

2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonists

A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure–activity analysis targeting their three pharmacophoric regions indicated that halogenated phenyl A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, respectively. Further, antagonist 92 displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A molecular modeling study of 92 indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.