340825-89-0Relevant academic research and scientific papers
Palladium-Catalyzed Picolinamide-Directed Benzylic C(sp3)?H Chalcogenation with Diaryl Disulfides and Diphenyl Diselenide
Wang, Kai,Hou, Jiahao,Zhang, Changjun,Cheng, Ke,Bai, Renren,Xie, Yuanyuan
, p. 2947 - 2952 (2020)
The first palladium-catalyzed direct benzylic C(sp3)?H chalcogenation with diaryl disulfides and diphenyl diselenide has been established. The coupling reaction proceeds between the thioether radical and palladiumcycle intermediate. Picolinamide serves as an excellent directing group for the C?H activation of benzylic C(sp3)?H and can be easily removed. The current protocol exhibits a relatively broad substrate scope and high functional group compatibility. A mechanistic study indicates that palladium(IV) intermediate is probably formed during the course of the reaction. (Figure presented.).
Synthesis of Benzyl Esters via Functionalization of Multiple C-H Bonds by Palladium Catalysis
Li, Danyang,Yu, Ming,Zhang, Jitan,Liu, Zhanxiang,Zhang, Yuhong
supporting information, p. 5300 - 5303 (2015/11/18)
A highly efficient, selective synthesis of benzyl esters by palladium catalysis is developed through the bidentate directing group assisted functionalization of multiple C(sp3)-H bonds.
Palladium-catalyzed oxidative acetoxylation of benzylic C-H bond using bidentate auxiliary
Ju, Long,Yao, Jinzhong,Wu, Zaihong,Liu, Zhanxiang,Zhang, Yuhong
, p. 10821 - 10831 (2013/11/19)
Pd(OAc)2-catalyzed oxidative acetoxylation of benzylic C-H bonds utilizing a bidentate system has been explored. A variety of picolinoyl- or quinoline-2-carbonyl-protected toluidine derivatives react with PhI(OAc) 2 in the presence of Pd(OAc)2 to afford the acetoxylated products in synthetically useful yields. A broad of functionalities, such as CH3, F, Cl, Br, I, COCH3, CO2Et, SO 2CH3, and NO2, were tolerated. This transformation provides easy access to 2-hydroxymethylaniline derivatives.
Pd-catalyzed arylation/oxidation of benzylic C-H bond
Xie, Yongju,Yang, Yuzhu,Huang, Lehao,Zhang, Xunbin,Zhang, Yuhong
supporting information; experimental part, p. 1238 - 1241 (2012/05/20)
A palladium-catalyzed benzylic C-H arylation/oxidation reaction leading to diaryl ketones has been accomplished. The indispensable role of the bidentate system is disclosed for this sequential process. This chemistry offers a direct new access to a range of diarylketones.
