340829-40-5Relevant academic research and scientific papers
Synthesis of substituted-δ2-1,2,4-triazolin-5-ones and S-substituted isothiobiureas from 1-aryl/alkyl-6-phenyl-2-thiobiureas
Suni,Nair,Joshua
, p. 1599 - 1605 (2007/10/03)
Reaction of 1-aryl/alkyl-6-phenyl-2-thiobiureas 1 with BnCl and BuI in neutral medium at reflux temperature resulted in the formation of the S-alkylated isothiobiureas 2 and 1,2,4-triazolin-5-one derivatives 3. A convenient route to 2 is also reported.
Heterocyclization of 1-aryl/alkyl-2-thiobiureas to 4-aryl/alkyl-3-substituted-Δ2-1,2,4-triazolin-5-ones
Suni,Nair, Vipin A,Joshua
, p. 2003 - 2009 (2007/10/03)
Synthesis of a range of 1,2,4-triazolin-5-ones has been carried out by thermally induced cyclization of 1-aryl/alkyl-2-alkyl isothiobiureas 4. The required isothiobiureas were generated in situ by the reaction of alkyl halides with 1-aryl/alkyl-2-thiobiureas 3 in acidic medium at reflux. The reaction proceeds after S-alkylation of the thiobiureas and is demonstrated by the isolation of the alkyl isothiobiurea intermediates and their subsequent acid catalyzed thermal cyclization.
