34084-81-6

Usage

Physical state

Yellow to green crystalline solid

Usage

Reagent in organic synthesis

Applications

a. Acetylating agent in the preparation of heterocyclic compounds
b. Reactant in the synthesis of pharmaceuticals and natural products
c. Flavoring agent in the food industry

Hazardous nature

Potentially hazardous chemical

Safety measures

Proper safety measures should be taken when handling

Upstream product

• 504-02-9 1,3-cylohexanedione 
• 78-94-4 methyl vinyl ketone 

Downstream Products

• 31526-72-4 3-methoxy-2-(3-oxo-butyl)-cyclohex-2-enone 
• 7195-71-3 3-(2-methyl-6-oxo-cyclohex-1-enyl)-propionic acid 
• 1108206-36-5 2-allyl-2-(3-oxobutyl)-1,3-cyclohexanedione 

Relevant academic research and scientific papers

Structural diversity and similar bioactivity in synthetic bicyclononanes

Simple syntheses of diverse bicyclo[3.3.1]nonanes and related compounds as the minimal substructure of bioactive natural products via Michael, aldol, and alkylation reactions from diketones are described herein. The structures of the synthesized compounds

Base Stable Ionic Liquids

The present invention relates to novel base stable ionic liquids and uses thereof as solvents in chemical reactions, especially base catalysed chemical reactions and reactions comprising the use of strong basis.

ZrCl4-catalyzed Michael reaction of 1,3-dicarbonyls and enones under solvent-free conditions

ZrCl4 has been found to catalyze the conjugate addition of 1,3-dicarbonyl compounds with enones. The reaction does not require any solvent and proceeds smoothly at room temperature leading to the corresponding adduct in good yields.

Synthesis of new chiral 6-carbonyl 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a] pyridines

The preparation of new chiral 6-carbonyl 2,3,8,8a-tetrahydro-7H-oxazolo[3, 2-a]pyridines by an efficient two-step procedure is described.

Indium(III) chloride catalyzed conjugate addition of 1,3-dicarbonyl compounds to α,β-unsaturated ketones

Indium trichloride catalyzes efficiently the Michael reactions of 1,3-dicarbonyl compounds with α,β-unsaturated ketones to afford the corresponding Michael adducts in high yields with high selectivity.

LITHIUM HYDROXIDE-CATALYZED CONJUGATE ADDITION OF β-DICARBONYL COMPOUNDS

Lithium hydroxide proves to be a very efficient catalyst for Michael addition of β-dicarbonyl compounds 1.The application of the methodology to α,γ-diketo esters and α-keto γ-diesters 4 allows an easy approach to δ-diketones and δ-keto esters 5, respectiv