34091-51-5

Usage

Uses

Used in Organic Synthesis:
5-IODO-1-METHYL-1H-PYRAZOLE is used as a building block for the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 5-IODO-1-METHYL-1H-PYRAZOLE is utilized as a key component in the development of new drugs. Its chemical properties make it a valuable asset in the design and synthesis of novel therapeutic agents.
Used in Antifungal Applications:
5-IODO-1-METHYL-1H-PYRAZOLE is studied for its potential as an antifungal agent, offering a possible solution for combating fungal infections. Its effectiveness in this area is currently under investigation.
Used in Antimicrobial Applications:
Similarly, 5-IODO-1-METHYL-1H-PYRAZOLE is being explored for its antimicrobial properties, which could contribute to the development of new treatments for bacterial infections.
Used in Chemical Research:
5-IODO-1-METHYL-1H-PYRAZOLE also serves as a subject of interest in chemical research, where its unique characteristics are examined to better understand its reactivity and potential applications in various chemical processes.

InChI:InChI=1/C4H5IN2/c1-7-4(5)2-3-6-7/h2-3H,1H3

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 

Downstream Products

• 3463-27-2 1-methyl-5-phenyl-1H-pyrazole 
• 1450597-12-2 5-(4,4-difluorocyclohex-1-en-1-yl)-1-methyl-1H-pyrazole 
• 1356997-45-9 1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole 
• 1047644-84-7 1,1-dimethylethyl [2-({[5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-2-phenylethyl]carbamate 
• 1069094-95-6 N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide 
• 1069093-36-2 N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide 
• 876316-68-6 1-methyl-5-(2-thienyl)-1H-pyrazole 
• 938066-21-8 2-(1-methyl-1H-5-pyrazolyl)pyridine 
• 64091-87-8 3-(1-methyl-1H-pyrazol-5-yl)pyridine 

Relevant academic research and scientific papers

FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS

The present description relates to fused polycyclic 2-pyridinone compounds and forms and pharmaceutical compositions thereof and methods of using such compounds, forms or compositions thereof for treating or ameliorating a wild-type or drug-resistant form of N. gonorrhoeae or N. meningitides. A compound of Formula (la), Formula (lb) or Formula (Ic), or a form thereof, wherein the dashed lines represent one or more double bonds optionally present where allowed by available valences.

Potassium-alkyl magnesiates: Synthesis, structures and Mg-H exchange applications of aromatic and heterocyclic substrates

Using structurally well-defined dipotassium-tetra(alkyl)magnesiates, a new straightforward methodology to promote regioselective Mg-H exchange reactions of a wide range of aromatic and heteroaromatic substrates is disclosed. Contacted ion pair intermediates are likely to be involved, with K being the key to facilitate the magnesiation processes. This journal is

ETHINYL-PYRAZOLE DERIVATIVE

Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof i

HETEROARYL-PYRAZOLE DERIVATIVE

A compound represented by formula [I] and a pharmaceutically accepted salt of said compound are a novel compound and a pharmaceutically accepted salt thereof which exert antagonistic activity against group II metabotropic glutamate (mGlu) receptors, and are effective as a novel preventive or therapeutic agent for disorders such as mood disorders (depressive disorder, bipolar disorder, etc.), anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, a specific phobic disorder, acute stress disorder, etc.), schizophrenia, Alzheimer's disease, cognitive impairment, dementia, drug dependence, convulsions, shivering, pain, sleep disorders, and the like.

Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)2 and applications in in situ cross coupling reactions

This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)2] 1 to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic molecules. The generated metallated intermediates from these reactions are intercepted with I2 and some of them are also employed as precursors in Pd-catalysed Negishi cross-coupling applications. A comparison with recent precedents in metallation chemistry reveals that for some of these heterocycles, 1 allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.

Regioselective Halo- and Carbodesilylation of (Trimethylsilyl)-1-methylpyrazoles

The isomeric 3-, 4-, and 5-(trimethylsilyl)- as well as the 3,4-, 3,5-, and 4,5-bis(trimethylsilyl)-1-methylpyrazoles (2, 7, 3, 5, 9, and 10, respectively) are obtained by methylation of the corresponding (trimethylsilyl)-1H-pyrazoles or by silylation of Grignard or lithio derivatives of appropriate 1-methylpyrazoles with chlorotrimethylsilane. 5 and 10 are halodesilylated regioselectively by Br2 or ICl in the 4-position, yielding 13 and 15.With addditional bromine, these monobromo compounds suffer exclusively bromodesilylation to give 3,4- and 4,5-dibromo-1-methylpyrazole (14 and 16, respectively).These findings are in accord with the electrophilic substitution reactivity indices for 1-methylpyrazole (8) and with ipso-directing influence of the Me3Si group.The reaction of 5 with I2, unexpectedly, attacks preferentially at the 3-position.Regioselective carbodesilylation in the 5-position is observed in the fluoride-catalyzed reactions of 3, 9, and 10 with carbon electrophiles.The high regiospecificity of this reaction is rationalized in terms of carbanion stabilization at the individual pyrazole positions.