34091-51-5

Basic information

• Product Name: 5-IODO-1-METHYL-1H-PYRAZOLE
• Synonyms: 5-IODO-1-METHYL-1H-PYRAZOLE;1-Methyl-5-iodopyrazole;5-Iodo-1-methylpyrazole
• CAS NO: 34091-51-5
• Molecular Formula: C₄H₅IN₂
• Molecular Weight: 208
• Mol File: 34091-51-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 80℃
• Boiling Point: 226.9±13.0℃ (760 Torr)
• Flash Point: 91.1±19.8℃
• Appearance: /
• Density: 2.07±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.12mmHg at 25°C
• Refractive Index: 1.681
• Storage Temp.: 2-8°C
• Solubility: soluble in Methanol
• PKA: 1.02±0.10(Predicted)
• Sensitive: Moisture & Light Sensitive
• CAS DataBase Reference: 5-IODO-1-METHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-1-METHYL-1H-PYRAZOLE(34091-51-5)
• EPA Substance Registry System: 5-IODO-1-METHYL-1H-PYRAZOLE(34091-51-5)

Safety Data

• Hazard Codes: Xi
• Statements: 37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 34091-51-5(Hazardous Substances Data)

Usage

General Description

5-Iodo-1-methyl-1H-pyrazole is a chemical compound with the molecular formula C4H5IN2. It is a pyrazole derivative that contains an iodo substituent and a methyl group on the first carbon atom. 5-IODO-1-METHYL-1H-PYRAZOLE is commonly used as a building block in organic synthesis and pharmaceutical research, particularly in the development of new drugs. It has also been studied for its potential antifungal and antimicrobial properties. 5-Iodo-1-methyl-1H-pyrazole is considered a hazardous chemical and should be handled with care due to its potential health and environmental risks.

InChI:InChI=1/C4H5IN2/c1-7-4(5)2-3-6-7/h2-3H,1H3

Upstream product

• 930-36-9 1-methyl-1H-pyrazole 

Downstream Products

• 876316-68-6 1-methyl-5-(2-thienyl)-1H-pyrazole 
• 64091-87-8 3-(1-methyl-1H-pyrazol-5-yl)pyridine 
• 938066-21-8 2-(1-methyl-1H-5-pyrazolyl)pyridine 
• 3463-27-2 1-methyl-5-phenyl-1H-pyrazole 
• 1450597-12-2 5-(4,4-difluorocyclohex-1-en-1-yl)-1-methyl-1H-pyrazole 
• 1356997-45-9 1-methyl-5-{[4-(trifluoromethyl)phenyl]ethynyl}-1H-pyrazole 
• 1047644-84-7 1,1-dimethylethyl [2-({[5-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-2-phenylethyl]carbamate 
• 1069094-95-6 N-[(2,4-dichlorophenyl)methyl]-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide 
• 1069093-36-2 N-[(2-chloro-3,4-difluorophenyl)methyl]-3-methyl-1-(1-methyl-1H-pyrazol-5-yl)-2-oxo-4-imidazolidinecarboxamide 

Relevant articles and documents

FUSED POLYCYCLIC 2-PYRIDINONE ANTIBACTERIAL COMPOUNDS

The present description relates to fused polycyclic 2-pyridinone compounds and forms and pharmaceutical compositions thereof and methods of using such compounds, forms or compositions thereof for treating or ameliorating a wild-type or drug-resistant form of N. gonorrhoeae or N. meningitides. A compound of Formula (la), Formula (lb) or Formula (Ic), or a form thereof, wherein the dashed lines represent one or more double bonds optionally present where allowed by available valences.

ETHINYL-PYRAZOLE DERIVATIVE

Provided is a novel compound represented by formula [I] or a pharmaceutically acceptable salt thereof having antagonistic activity against group II metabolism-type glutamic acid (m-Glu) receptors. The compound or pharmaceutically acceptable salt thereof i

Alkali-metal mediated zincation of N-heterocyclic substrates using the lithium zincate complex, (THF)Li(TMP)Zn(tBu)2 and applications in in situ cross coupling reactions

This study investigates the ability of the mixed-metal reagent [Li(TMP)Zn(tBu)2] 1 to promote direct Zn-H exchange reactions (zincations) of a wide range of N-heterocyclic molecules. The generated metallated intermediates from these reactions are intercepted with I2 and some of them are also employed as precursors in Pd-catalysed Negishi cross-coupling applications. A comparison with recent precedents in metallation chemistry reveals that for some of these heterocycles, 1 allows improved conversions, under milder conditions and in certain cases, even gives unique regioselectivities.