340963-75-9

Upstream product

• 136918-14-4 phthalimide 
• 340963-38-4 (R)-2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethanol 
• 82807-38-3 1-(2-methoxyphenyl)ethane-1,2-diol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 340963-74-8 (S)-1-(2-methoxy-3-nitrophenyl)ethane-1,2-diol 
• 340963-73-7 (S)-acetic acid 2-acetoxy-2-(2-methoxyphenyl)ethyl ester 
• 340963-36-2 (S)-acetic acid 2-acetoxy-2-(2-methoxy-3-nitrophenyl)ethyl ester 

Downstream Products

• 340963-60-2 (R)-allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]amine 
• 340963-43-1 (S)-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)amine 
• 340963-72-6 N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-formyl-8-methoxy-3-oxo-1,2,3,4-tetrahydro-isoquinolin-7-yl]-acetamide 
• 340963-77-1 acetic acid {allyl-[1-(3-amino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamoyl}-methyl ester 
• 340963-70-4 (R)-N-[1-(tert-butyldiphenylsilanyloxymethyl)-8-methoxy-3-oxo-2-propenyl-1,2,3,4-tetrahydroisoquinolin-7-yl]acetamide 
• 340963-62-4 (R)-acetic acid {allyl-[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]carbamoyl}methyl ester 
• 340963-66-8 (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-N-allyl-2-hydroxyacetamide 
• 340963-68-0 (R)-N-[2-allyl-1-(tert-butyldiphenylsilanyloxymethyl)-8-methoxy-3-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl]acetamide 
• 340963-67-9 N-[(1R,4S)-2-allyl-1-(tert-butyldiphenylsilanyloxymethyl)-4-hydroxy-8-methoxy-3-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl]acetamide 
• 340963-64-6 (R)-acetic acid {[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]allylcarbamoyl}methyl ester 
• 340963-53-3 N-[1-(3-acetylamino-2-methoxy-phenyl)-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-N-(4-methoxy-benzyl)-2-oxo-acetamide 
• 340963-51-1 (R)-N-[1-(3-acetylamino-2-methoxyphenyl)-2-(tert-butyldiphenylsilanyloxy)ethyl]-2-hydroxy-N-(4-methoxybenzyl)acetamide 
• 340963-46-4 (R)-acetic acid [[2-(tert-butyldiphenylsilanyloxy)-1-(2-methoxy-3-nitrophenyl)ethyl]-(4-methoxybenzyl)carbamoyl]methyl ester 
• 340963-55-5 (R)-N-[1-(tert-butyldiphenylsilanyloxy)-4-hydroxy-8-methoxy-2-(4-methoxybenzyl)-3-oxo-1,2,3,4-tetrahydroisoquinolin-7-yl]acetamide 

Relevant academic research and scientific papers

Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine

The synthesis of the 1,2,3,4-tetrahydroisoquinoline moiety of tetrazomine was accomplished in 18 steps and in 3% overall yield from commercially available o-anisaldehyde. The reaction sequence utilizes a Sharpless asymmetric dihydroxylation to install the stereocenter and an intramolecular Friedel-Crafts hydroxyalkylation with an N-protected 2-oxo-acetamide to close the heterocyclic ring.