341006-17-5

Upstream product

• 60710-39-6 3-bromo-p-cresol 
• 107-30-2 chloromethyl methyl ether 
• 109-87-5 Dimethoxymethane 

Downstream Products

• 1596367-36-0 2-bromo-3-methoxymethoxy-6-methyl-benzaldehyde 
• 1596367-37-1 2-(2-bromo-3-methoxymethoxy-6-methylphenyl)-2-((trimethylsilanyl)oxy)acetonitrile 
• 1596367-39-3 methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-hydroxyacetate 
• 1596367-38-2 methyl 2-(2-bromo-3-hydroxy-6-methylphenyl)-2-hydroxyacetate 
• 1596367-40-6 methyl 2-[3-benzyloxy-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-hydroxyacetate 
• 1596367-47-3 methyl 2-(3-benzyloxy-2-bromo-6-methylphenyl)-2-(tert-butoxy)-acetate 
• 1596367-48-4 methyl 2-[3-benzyloxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]]-2-(tert-butoxy)acetate 
• 1596367-49-5 methyl 2-(tert-butoxy)-2-[3-hydroxy-6-methyl-2-[5-methyl-(3,4-dihydro-2H-1-benzopyran-6-yl)]phenyl]acetate 
• 1596367-35-9 5-methoxymethox-2-methyl-benzaldehyde 

Relevant academic research and scientific papers

KRAS G12D INHIBITORS

The present invention relates to compounds that inhibit KRas G12D. In particular, the present invention relates to compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor.

Preparation of labeled aromatic amino acids: Via late-stage18F-fluorination of chiral nickel and copper complexes

A general protocol for the preparation of 18F-labeled AAAs and α-methyl-AAAs applying alcohol-enhanced Cu-mediated radiofluorination of Bpin-substituted chiral complexes using Ni/Cu-BPX templates as double protecting groups is reported. The chiral auxiliaries are easily accessible from commercially available starting materials in a few synthetic steps. The versatility of the method was demonstrated by the high-yielding preparation of a series of [18F]F-AAAs and the successful implementation of the protocol into automated radiosynthesis modules. This journal is

Methoxymethylation of substituted alcohols using dimethoxymethane over Mo(VI)/ZrO2

The methoxymethylation reaction of alcohols was studied on Mo/ZrO2 (MZ) catalysts. The catalyst containing 5, 10 and 15 % Mo(VI) ions was prepared by solution combustion method. These solid acid catalytic materials were characterized by NH3- TPD, powder XRD, BET, FTIR spectroscopy, scanning electron microscopy, transmission electron spectroscopy and ICP- OES techniques. These catalysts were evaluated for their catalytic activity in the synthesis of methoxymethylation reactions of various substituted alcohols with dimethoxymethane in shorter reaction times (20 min) at moderate temperature (40 °C) with excellent yields (around 99 %). The main features of the Mo/ZrO2 catalyzed reaction are high yields, ease of scale up to gram scale, recyclable catalysts, inexpensive reagents, ecofriendly catalysts and a solvent free approach for the synthesis of methoxymethylated products.

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Inhibitors of viral replication, their process of preparation and their therapeutical uses

The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES

Inhibitors of viral replication of formula (I), their process of preparation and their therapeutical uses. The present invention relates to compounds, their use in the treatment or the prevention of viral disorders, including HIV.

Vitamin D analogues

The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in car