5442-34-2

Basic information

• Product Name: ethyl (1Z)-2-phenylethanimidoate
• CAS NO: 5442-34-2
• Molecular Formula: C₁₀H₁₃NO*ClH
• Molecular Weight: 163.2163
• Mol File: 5442-34-2.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 226.7°C at 760 mmHg
• Flash Point: 90.9°C
• Density: 0.97g/cm³
• Vapor Pressure: 0.121mmHg at 25°C
• Refractive Index: 1.499
• CAS DataBase Reference: ethyl (1Z)-2-phenylethanimidoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (1Z)-2-phenylethanimidoate(5442-34-2)
• EPA Substance Registry System: ethyl (1Z)-2-phenylethanimidoate(5442-34-2)

Safety Data

• Hazardous Substances Data: 5442-34-2(Hazardous Substances Data)

Upstream product

• 140-29-4 phenylacetonitrile 
• 115-10-6 Dimethyl ether 
• 64-17-5 ethanol 

Downstream Products

• 126-84-1 2,2-diethoxypropane 
• 75-00-3 chloroethane 
• 103-81-1 Benzeneacetamide 
• 58635-82-8 (S,S)-2-benzyl-4-methoxymethyl-5-phenyl-2-oxazoline 
• 2654-12-8 2-benzyl-3H-imidazo<4,5-b>pyridine 
• 141805-78-9 N-(Phenylacetyl)fumarsaeure-amid-pentylester 
• 175226-83-2 (4S)-2-benzyl-4-isopropyl-4,5-dihydrooxazole 
• 151410-81-0 N-(3-(Benzyloxy)-2-pyridyl)phenylacetamidine 
• 1161835-12-6 N-[1-((R)-2-Cyclopentyl-2-hydroxy-2-phenylacetyl)piperidin-4-yl]-2-phenylacetamidine 
• 937047-96-6 C₂₀H₂₃BN₂O₂ 
• 60576-64-9 5-Benzyl-1,3,4-thiadiazol-2(3H)-on 
• 110718-40-6 N-Butyl-2-phenyl-N'-[5-(2-trifluoromethyl-phenyl)-[1,3,4]thiadiazol-2-yl]-acetamidine 
• 110718-30-4 N-(5-Benzyl-[1,3,4]thiadiazol-2-yl)-2-phenyl-acetamidine 
• 175226-70-7 (5R)-3,5-diphenyl-5,6-dihydro-2H-1,4-oxazin-2-one 

Relevant articles and documents

Colchicine derivatives, and preparation method and medical application thereof

The invention specifically relates to colchicine derivatives (I) as described in the specification and a preparation method thereof, and pharmaceutical compositions containing the colchicine derivatives, belonging to the field of medicinal chemistry. The results of pharmacodynamic experiments prove that the colchicine derivatives of the invention have treatment effect on lumbar disc herniation andliver fibrosis.

Copper(II)-Mediated Aerobic Oxidation of Benzylimidates: Synthesis of Primary α-Ketoamides

A simple and straightforward method for the synthesis of primary α-ketoamides has been discovered. The reaction represents the first example of benzylimidates directly converting to primary α-ketoamides by using sustainable molecular oxygen as an oxidant. This reaction proceeds in the presence of copper(II) salt via cleavage of benzylic C-H and C-O bonds of the benzylimidates with liberation of alcohols as the only byproduct. A wide substrate scope, operationally mild conditions, the use of single substrates, and a reaction scaled up to grams make this strategy very attractive and practical. Furthermore, mechanistic studies illustrate that the imidate group adjacent to the benzylic position plays crucial role in facilitating this chemical process.

Copper(II)-Catalyzed Benzylic C(sp3)-H Aerobic Oxidation of (Hetero)Aryl Acetimidates: Synthesis of Aryl-α-ketoesters

A straightforward method is developed in this paper for the synthesis of α-ketoesters through copper-catalyzed aerobic oxidation of (hetero)aryl acetimidates using molecular oxygen as a sustainable oxidant. The reaction represents the first example of the direct synthesis of aryl-α-ketoesters from arylacetimidates through the aerobic oxidation of a benzylic C(sp3)-H (CO) bond in moderate to good yield. This transformation occurs under mild reaction conditions with a wide range of substrates and utilizes a readily available oxidant and catalyst. The synthetic utility of this transformation is demonstrated through scaled-up synthesis. A plausible reaction mechanism is also proposed.