34107-53-4Relevant academic research and scientific papers
Simplified synthesis of aryliodonium ylides by a one-pot procedure
Cardinale, Jens,Ermert, Johannes
supporting information, p. 2067 - 2069 (2013/04/23)
A simplified synthesis of iodonium ylides was developed by the one-pot synthesis of phenyliodonium-(5-[2,2-dimethyl-1,3-dioxane-4,6-dione]) ylide as a model system. Such ylides are excellent precursors for nucleophilic no-carrier-added 18F-fluorination of even non-activated arenes. The suitability of the one-pot method is exemplified for several electron rich iodonium ylides. Further, the syntheses of 2-, 3- and 4-bromophenyliodonium-(5- [2,2-dimethyl-1,3-dioxane-4,6-dione]) ylide, and 4-iodophenyliodonium-(5-[2,2- dimethyl-1,3-dioxane-4,6-dione]) ylide, two novel precursors for 4-[ 18F]fluoro-1-halobenzene, are reported.
NO-CARRIER-ADDED NUCLEOPHILIC [F-18] FLUORINATION OF AROMATIC COMPOUNDS
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Page/Page column 8-9, (2010/11/03)
Phenyliodonium ylide derivatives substituted with electron donating as well as electron withdrawing groups on the aromatic ring are shown for use as precursors in aromatic nucleophilic substitution reactions. The iodonium ylide group is substituted by nucleophiles such as halide ions to provide the corresponding haloaryl derivatives. No- carrier-added [F-18]fluoride ion exclusively substitutes the iodonium ylide moiety in these derivatives and provides high specific activity F- 18 labeled fluoro derivatives. Protected L-dopa-6-iodonium ylide derivative have been synthesized as a precursors for the preparation of no-carrier-added 6-[F- 18]fluoro-L-dopa. The iodonium ylide group in this L-dopa.derivative is nucleophilically substituted by no-carrier-added [F-18]fluoride ion to provide a [F-18]fluoro intermediates which upon acid hydrolysis yielded 6-[F- 18]fluoro-L-dopa.
