34114-57-3Relevant academic research and scientific papers
Resolution of racemic 2-amino-1-butanol with immobilised penicillin G acylase
Fadnavis,Sharfuddin, Mohd.,Vadivel
, p. 4495 - 4500 (1999)
Racemic 2-amino-1-butanol has been resolved to obtain (S)-2-amino-1- butanol with >99% e.e. via enantioselective hydrolysis of its N-phenylacetyl derivative with penicillin G acylase immobilised on Eupergit C. (C) 1999 Elsevier Science Ltd.
Efficient continuous kinetic resolution of racemic 2-aminobutanol over immobilized penicillin G acylase
Wang, Jianxin,Liu, Na,Cheng, Xiaobo,Chen, Ligong
supporting information, p. 956 - 962 (2016/07/07)
In this paper, an efficient method was established for continuous kinetic resolution of racemic 2-aminobutanol by selective hydrolysis of N-phenylacetyl (±)-2-aminobutanol over immobilized penicillin G acylase (PGA) in a fixed-bed reactor. Several N-acylated derivatives of 2-aminobutanol were screened in batch experiments, and it was found that the hydrolysis of N-phenylacetyl (±)-2-aminobutanol proceeded smoothly in the presence of immobilized penicillin G acylase with satisfied enantioselectivity. Thus, the reaction parameters were optimized in a fixed-bed reactor. Under the optimized conditions, 39.3% conversion of N-phenylacetyl (±)-2-aminobutanol and 98.2% ee value of S-2-aminobutanol were obtained. This fixed-bed system was operated continuously for 40?h without significant decrease of enzyme activity. It has been demonstrated to be more efficient compared to the batch experiments.
Ammonium nitrate: A biodegradable and efficient catalyst for the direct amidation of esters under solvent-free conditions
Ramesh, Perla,Fadnavis, Nitin W.
supporting information, p. 138 - 140 (2015/02/19)
A simple, metal-free, and environment-friendly procedure is developed for the direct conversion of esters to amides using ammonium nitrate as a catalyst under solvent-free conditions. Aryls, heteroaryls, and aliphatic esters are easily converted to the corresponding amides in excellent isolated yields (85-99%). An enantiopure ester and amine were both shown to react without racemization. The methodology has been successfully applied to preparation of procainamide.
