34117-90-3

Basic information

• Product Name: 2 CHLORO-3-AMINO QUINOXALINE
• Synonyms: 3-CHLORO-2-QUINOXALINAMINE;3-AMINO-2-CHLOROQUINOXALINE;2 CHLORO-3-AMINO QUINOXALINE;2-AMINO-3-CHLOROQUINOXALINE;TIMTEC-BB SBB005632;3-Amino-2-chloroquinoxaline 3-Chloro-2-quinoxalinamine;3-Chloroquinoxaline-2-amine;3-Chloroquinoxalin-2-amine
• CAS NO: 34117-90-3
• Molecular Formula: C₈H₆ClN₃
• Molecular Weight: 179.61
• Product Categories: API intermediates
• Mol File: 34117-90-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 289℃
• Flash Point: 129℃
• Appearance: /
• Density: 1.445
• Vapor Pressure: 0.00226mmHg at 25°C
• Refractive Index: 1.726
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2 CHLORO-3-AMINO QUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2 CHLORO-3-AMINO QUINOXALINE(34117-90-3)
• EPA Substance Registry System: 2 CHLORO-3-AMINO QUINOXALINE(34117-90-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34117-90-3(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-amino quinoxaline is a chemical compound that belongs to the class of organic compounds known as quinoxalines. 2 CHLORO-3-AMINO QUINOXALINE is chiefly recognized for its application in the pharmaceutical industry due to its functionality and structures that can be manipulated to produce various active pharmaceutical ingredients. The compound's chloro, amino group, and quinoxaline structure make it highly reactive and versatile. The presence of the chlorine atom gives 2-Chloro-3-amino quinoxaline high reactivity while the amino group increases its basicity, and the quinoxaline group aids in the production of dyes and pharmaceuticals. Despite its industrial and cosmetic potential, little is known about the toxicity and environmental impact of this compound.

InChI:InChI=1/C8H6ClN3/c9-7-8(10)12-6-4-2-1-3-5(6)11-7/h1-4H,(H2,10,12)

Upstream product

• 87885-47-0 2-chloro-3-nitroquinoxaline 
• 35015-91-9 3-amino-2(1H)-quinoxalinone 

Downstream Products

• 251537-64-1 3-(4-phenyl-piperazin-1-yl)-quinoxalin-2-ylamine 
• 251537-52-7 3-(2,4-dichloro-benzyloxy)-quinoxalin-2-ylamine 
• 251537-54-9 3-(2,6-dichloro-benzyloxy)-quinoxalin-2-ylamine 
• 251537-43-6 3-(4-chloro-benzyloxy)-quinoxalin-2-ylamine 
• 251537-41-4 3-benzyloxy-quinoxalin-2-ylamine 
• 452311-42-1 2-amino-3-(methylamino)quinoxaline 
• 127376-25-4 Phenyl-(4a,5,10,11-tetraaza-benzo[b]fluoren-2-yl)-methanone 
• 1422179-79-0 3-aminoquinoxalin-2-yldiphenylphosphine oxide 
• 5424-05-5 quinoxalin-2-ylamine 
• 1422239-76-6 2-amino-3-diphenylphosphanylquinoxaline 
• 1079-66-9 chloro-diphenylphosphine 
• 1101-41-3 Tetraphenyldiphosphin 
• 4559-70-0 Diphenylphosphine oxide 
• 1226502-06-2 2,3-dichloro-N-{3-[(pyridin-3-yl)methoxy]quinoxalin-2-yl}-benzenesulfonamide 

Relevant articles and documents

Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives

The reaction of o-phenylene diamine and ethyl oxamate is reinvestigated and led to 3-aminoquinoxalin-2(1H)-one rather than benzimidazole-2-carboxamide as was previously reported. The structure of the obtained quinoxaline has been confirmed by X-ray. The anti-tumor activity of synthesized quinoxalines 1-21 has been evaluated by studying their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13- acetate (TPA). Among the studied compounds 1-21, compounds 12, 8, 13, 18, 17 and 19, respectively, demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity and their effects being stronger than that of a representative control, oleanolic acid. Furthermore, compound 12 exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. The result of the present investigation indicated that compound 12 might be valuable as a potent cancer chemopreventive agent. Moreover, the molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors.

A FACILE SYNTHESIS OF NOVEL TRICYCLIC COMPOUNDS, TETRAZOLOQUINOXALINES AND 1,2,4-TRIAZOLOQUINOXALINES

Novel 5-methyltetrazoloquinoxalin-4-ones (5) and 5-methyl-1,2,4-triazoloquinoxalin-4-ones (7) could be synthesized from 1-methyl-3-chloroquinoxalin-2-ones (3) and 1-methyl-3-hydrazinoquinoxalin-2-ones (6), respectively.Further extensive study was carried out to synthesize 4- or 7- substituted and 4,7-disubstituted tetrazoloquinoxalines (10) and 1,2,4-triazoloquinoxalines (12).