35015-91-9Relevant academic research and scientific papers
Applications of ethyl carboethoxyformimidate to heterocyclic synthesis: Preparation of condensed pyrazinones and 1,4-oxazinones
McKillop, Alexander,Chattopadhyay, Shital K.,Henderson, Alan,Avendano, Carmen
, p. 301 - 304 (1997)
Aromatic and heteroaromatic 1,2-diamines, and o-aminophenols, condense smoothly with ethyl carboethoxyformimidate to give good yields of condensed pyrazinones and 1,4-oxazinones.
Exploration of quinoxaline derivatives as antimicrobial and anticancer agents
Bayoumi, Ashraf H.,Ghiaty, Adel H.,Abd El-Gilil, Shimaa M.,Husseiny, Ebtehal M.,Ebrahim, Maha A.
, p. 3215 - 3235 (2019/11/16)
Novel 2 and 3-substituted quinoxaline derivatives were synthesized through various synthetic pathways, among which cyanoacetamide and cyanoacetohydrazide quinoxaline derivatives 4a-c and 11a-c, respectively, were synthesized. Furthermore, methoxy quinoxaline derivatives 3c and quinoxaline derivatives bearing substituted pyridines 6a,b, 12a,b, and 13a,b were designed to be synthesized. However, we have synthesized acrylohydrazide 5a,b and 7/acrylamide derivatives, Schiff base analogues 14a-f, pyrazole derivatives 15a-e, amide derivatives 16a-f, guanidine derivatives 16 g,h as well as, quinoxalin-2-methylallyl propionate derivative 14g. All the synthesized compounds were confirmed via spectral data and elemental analyses. Moreover, the newly synthesized compounds were evaluated for their antimicrobial activity (Gm +ve, Gm ?ve in comparison to Gentamycin a standard) and fungi (in comparison to Ketoconazole as a standard). Thus, compound 16b showed promising antimicrobial activity against B. subtilis, P. vulgaris, and S. mutants with values ranging from 20 to 27-mm zone of inhibition. While compounds 5a, 14e,f, and 16a,c,d,g,h showed potent antimicrobial activity. Moreover, the National Cancer Institute (NCI) selected 20 compounds that were submitted for anticancer screening against 60 types of cancer cell lines. The most active compounds are 5b and 12a where compound 5b containing 2,4-dichlorophenyl moiety at cyanoacetamide linkage of hydrazine quinoxaline backbone exerted significant growth inhibition activity against Leukemia MOLT-4, Renal cancer UO-31, and Breast cancer MCF-7. In addition, compound 12a having 4,6-diaminopyridinone side chain at position-3 of quinoxaline nucleus exhibited remarkable anticancer activity against renal cancer UO-31.
Direct C(sp2)?H Amination to Synthesize Primary 3-aminoquinoxalin-2(1H)-ones under Simple and Mild Conditions
Yang, Qiming,Yang, Zibing,Tan, Yushi,Zhao, Jiquan,Sun, Qian,Zhang, Hong-Yu,Zhang, Yuecheng
supporting information, p. 1662 - 1667 (2019/02/19)
A convenient C?H amination of quinoxalin-2-ones has been developed. This transformation provides concise access to 3-aminoquinoxalin-2(1H)-ones with a broad tolerance of functional groups, utilizing TMSN3 as an amino source under simple and mild conditions. The target 3-aminoquinoxalin-2(1H)-ones are important intermediates for the synthesis of biologically active 3-N-substituted quinoxalin-2-one derivatives. (Figure presented.).
Synthesis and docking studies of novel antitumor benzimidazoles
Omar, Mohamed A.,Shaker, Yasser M.,Galal, Shadia A.,Ali, Mamdouh M.,Kerwin, Sean M.,Li, Jing,Tokuda, Harukuni,Ramadan, Raghda A.,El Diwani, Hoda I.
, p. 6989 - 7001 (2013/01/15)
In this work, the benzimidazole-pyrrole conjugates 6a-h and benzimidazole-tetracycles conjugates 12-14 were prepared. The cytotoxicity of the compounds 3, 4a-h, 6a-h, 8, 10 and 12-14 was tested against lung cancer cell line A549. Compound 6b exhibited higher activity than the bis-benzoxazole natural product (UK-1), the standard. The tested 4g,h, 6a-h, 10 and 12-14 exhibited remarkable cytotoxicity activity against breast cancer cell line MCF-7 with higher activity than tamoxifen. Furthermore, compound 4h was found to be also more potent than doxurubicin. The antitumor promotion activity of synthesized compounds 4g,h, 6a-h, 10 and 12-14 has been estimated by studying their possible inhibitory effects on EBV-EA activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the studied compounds, the inhibitory activities of compounds 8, 13 and 14 demonstrated strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity on the Raji cells and their effects being stronger than that of a representative control, oleanolic acid. Moreover, the molecular docking of the new compounds into plasminogen activator (uPA) receptor has been in correlation with the antitumor activity. All synthesized compounds 3, 4a-h, 6a-h, 8, 10 and 12-14 were docked into same groove of the binding site of the native co-crystalized (4-iodobenzo[b]thiophene-2-carboxamidine) ligand (PDB code:1c5x) for activity explaination. Compounds 4h, 6b and 13, giving the best docking results, were further studied to estimate their effect on the level of uPA using AssayMax human urokinase (uPA) ELISA kit. In case of A549 cell line, compound 6 exhibited similar activity to MMC, and for MCF-7 cell line, compound 4h exhibited similar activity to doxorubicin, in inhibiting the expression of uPA.
Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives
Galal, Shadia A.,Abdelsamie, Ahmed S.,Tokuda, Harukuni,Suzuki, Nobutaka,Lida, Akira,Elhefnawi, Mahmoud M.,Ramadan, Raghda A.,Atta, Mona H.E.,El Diwani, Hoda I.
experimental part, p. 327 - 340 (2011/02/25)
The reaction of o-phenylene diamine and ethyl oxamate is reinvestigated and led to 3-aminoquinoxalin-2(1H)-one rather than benzimidazole-2-carboxamide as was previously reported. The structure of the obtained quinoxaline has been confirmed by X-ray. The anti-tumor activity of synthesized quinoxalines 1-21 has been evaluated by studying their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13- acetate (TPA). Among the studied compounds 1-21, compounds 12, 8, 13, 18, 17 and 19, respectively, demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity and their effects being stronger than that of a representative control, oleanolic acid. Furthermore, compound 12 exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. The result of the present investigation indicated that compound 12 might be valuable as a potent cancer chemopreventive agent. Moreover, the molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors.
Regioselectivity in preparation of unsymmetrically substituted 3-aminoquinoxalin-2(1H)-ones
Csikos, Eva,Goenczi, Csaba,Podanyi, Benjamin,Toth, Gabor,Hermecz, Istvan
, p. 1789 - 1793 (2007/10/03)
Regioisomer formation has to be considered in the preparation of quinoxalines having different substituents at the 2- and 3-position. Oxalomonoimidic acid dimethyl ester or oxalompnoimidic acid diethyl ester, chloro(methyl- , imino)acetic acid ethyl ester, chloro[(Z)-hydroxyimino]acetic acid ethyl ester and (Z)-2-[(E)-hydroxyimino]acetohydroximoyl chloride were applied to the synthesis of 3-aminoquinoxalin-2(1H)-one derivatives, and the isomer ratio was investigated concerning the reactivity of the ring-closure reagent. The structures of reaction products . were identified using 1H, 13C and 15N NMR techniques. A direct synthesis of quinoxaline-2,3(1H,4H)-dione 3-oximes is described.
Glycine receptor antagonist pharmacophore
-
, (2008/06/13)
Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer''s disease, amyotrophic lateral sclerosis, Huntington''s disease and Down''s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a compound which has high binding to the glycine receptor.
Reactions of hydroxylamines with ethyl cyanoformate. Preparation of aminonitrones and their synthetic applications
Branco,Prabhakar,Lobo,Williams
, p. 6335 - 6360 (2007/10/02)
The reaction of hydroxylamines with ethyl cyanoformate 1 leads to the formation of carbethoxyamino nitrones. 2. UV spectroscopy provided information that suggested the nitrone structure for these compounds in solution. X-ray analysis of 2a confirmed that it exists entirely in the nitrone form in the solid state. These nitrones are shown to be excellent starting materials for a variety of nitrogen containing compounds, namely, imidazoles, benzimidazoles, benzimidazolones, oxadiazolones, N-arylamidines and quinoxalone.
HETEROCYCLIC SYNTHESIS USING ETHYL CARBOETHOXYFORMIMIDATE
McKillop, Alexander,Henderson, Alan,Ray, Partha S.,Avendano, Carmen,Molinero, Encarnacion G.
, p. 3357 - 3360 (2007/10/02)
Ethyl carboethoxyformimidate is shown to be a versatile reagent for the synthesis of a variety of mono- and bicyclic heterocyclic systems.
