34126-15-3

Upstream product

• 51946-01-1 m-ClC₆H₄SGe(CH₃)3 
• 75-03-6 ethyl iodide 
• 64-17-5 ethanol 
• 2402-00-8 1-chloro-3-thiocyanatobenzene 
• 2037-31-2 3-chlorophenylthiol 
• 118736-30-4 1,1-bis(benzenesulphonyl)-4-(3-chlorobenzenethio)butane 
• 118736-25-7 1,1-bis(benzenesulphonyl)-3-(3-chlorobenzenethio)propane 
• 118736-24-6 1-(3-chlorobenzenethio)-2-iodoethane 
• 118736-35-9 1,1-bis(benzenesulphonyl)-5-(3-chlorobenzenethio)pentane 

Downstream Products

• 1227370-61-7 1-bromo-4-(ethylsulfonyl)-2-chlorobenzene 
• 1005206-32-5 (4-bromo-3-chlorophenyl)(ethyl)sulfane 

Relevant academic research and scientific papers

DI-SUBSTITUTED PYRAZOLE COMPOUNDS FOR THE TREATMENT OF DISEASES

Provided herein are compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds and compositions in treating a condition, disease, or disorder associated with abnormal activation of the SREBP pathway, including meta

NAPHTHYLACETIC ACIDS

The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts and esters thereof, wherein X, Q, and R1-R6 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists or partial agonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.

The reaction of (Arylthio)trimethylgermanes with various haloalkanes -Steric effect on the reaction mechanism-

A kinetic study has been conducted on the reactions of (arylthio) trimethylgermanes with various haloalkanes. Bimolecular nucleophilic attack of the sulfur atom has been found as the mechanisms for the reactions with normal haloalkanes while the mechanism was found to deviate from bimolecular attack to unimolecular ionization of the haloalkane, dependent on the structure of the alkyl groups with increasing of the steric hindrance. Reaction of a secondary haloalkane also proceeded by unimolecular ionization.

TRANSITION STATES IN INTRAMOLECULAR SN2 REACTIONS OF CARBANIONS. THE CLOSURE OF THREE-, FOUR- AND FIVE-MEMBERED RINGS

The intramolecular displacement of aryl ethyl sulphonium by carbanions stabilised by two sulphonyl groups has been studied.Rates of cyclisation of three-, four- and five-membered rings follow the same trend observed in the analogous displacement of halides.The effects of substituents on the leaving group show that, in the series considered, variations in the extent of bond cleavage to the leaving group are small.