34145-05-6

Usage

Uses

Used in Chemical Synthesis:
2,5-Dichlorobenzyl alcohol is used as a reactant in the chemical synthesis of aldehydes and ketones. Its application is crucial for the production of a wide range of organic compounds, which can be utilized in various industries, including pharmaceuticals, agrochemicals, and the fragrance industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Dichlorobenzyl alcohol is used as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its ability to be oxidized to aldehydes or ketones makes it a valuable component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
2,5-Dichlorobenzyl alcohol is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other agricultural chemicals. Its role in the production of these compounds contributes to the development of more effective and targeted pest control solutions.
Used in Fragrance Industry:
In the fragrance industry, 2,5-Dichlorobenzyl alcohol is employed as a starting material for the creation of various scent compounds. Its chemical properties make it suitable for the development of unique and complex fragrances used in perfumes, cosmetics, and other scented products.
Overall, 2,5-Dichlorobenzyl alcohol is a versatile chemical compound with a wide range of applications across different industries, primarily due to its role in the catalyzed oxidation of alcohols to aldehydes or ketones. Its chemical properties and reactivity make it an essential component in the synthesis of various organic compounds, contributing to the development of new products and technologies in the pharmaceutical, agrochemical, and fragrance industries.

InChI:InChI=1/C7H6Cl2O/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H2

Upstream product

• 50-79-3 2,5-dichlorobenzoic acid 
• 2905-69-3 methyl 2,5-dichlorobenzoate 
• 100-52-7 benzaldehyde 
• 2745-49-5 1,4-Dichloro-2-chloromethyl-benzene 
• 6361-23-5 2,5-dichloro-benzaldehyde 

Downstream Products

• 5330-38-1 4-chloro-2-hydroxymethylphenol 
• 102049-25-2 2.5-Dichlor-benzyloxycarbonylmethyl-triphenyl-phosphonium-chlorid 
• 90273-71-5 Chlor-essigsaeure-(2,5-dichlor-benzylester) 
• 14225-80-0 2-(2,5-dichlorophenyl)-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides

New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.

Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor

The sphingomyelin synthase 2 (SMS2) is a potential target for pharmacological intervention in atherosclerosis. However, so far, few selective SMS2 inhibitors and their pharmacological activities were reported. In this study, a class of 2-benzyloxybenzamides were discovered as novel SMS2 inhibitors through scaffold hopping and structural optimization. Among them, Ly93 as one of the most potent inhibitors exhibited IC50 values of 91 nM and 133.9 μM against purified SMS2 and SMS1 respectively. The selectivity ratio of Ly93 was more than 1400-fold for purified SMS2 over SMS1. The in vitro studies indicated that Ly93 not only dose-dependently diminished apoB secretion from Huh7 cells, but also significantly reduced the SMS activity and increased cholesterol efflux from macrophages. Meanwhile, Ly93 inhibited the secretion of LPS-mediated pro-inflammatory cytokine and chemokine in macrophages. The pharmacokinetic profiles of Ly93 performed on C57BL/6J mice demonstrated that Ly93 was orally efficacious. As a potent selective SMS2 inhibitor, Ly93 significantly decreased the plasma SM levels of C57BL/6J mice. Furthermore, Ly93 was capable of dose-dependently attenuating the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice treated with Ly93. In conclusion, we discovered a novel selective SMS2 inhibitor Ly93 and demonstrated its anti-atherosclerotic activities in vivo. The preliminary molecular mechanism-of-action studies revealed its function in lipid homeostasis and inflammation process, which indicated that the selective inhibition of SMS2 would be a promising treatment for atherosclerosis.

ANTI-HCMV COMPOSITIONS AND METHODS

This document relates to compounds useful as agents for preventing or treating human cytomegalovirus (HCMV) infections.

Hydrogenation of Esters to Alcohols Catalyzed by Defined Manganese Pincer Complexes

The first manganese-catalyzed hydrogenation of esters to alcohols has been developed. The combination of Mn(CO)5Br with [HN(CH2CH2P(Et)2)2] leads to a mixture of cationic and neutral Mn PNP pincer complexes, which enable the reduction of various ester substrates, including aromatic and aliphatic esters as well as diesters and lactones. Notably, related pincer complexes with isopropyl or cyclohexyl substituents showed very low activity.