34148-01-1 Usage
Originator
Indanal,Takeda,Japan,1981
Manufacturing Process
N-chlorosuccinimide (8.2 g.0.0614 mol) was added to a stirred, cooled (icewater) solution of (±)-5-cyclohexyl-1-indancarboxylic acid (10.0 g, 0.0409
mol) in dimethylformamide (82 ml). The solution was stirred for fifteen
minutes at 0°C. thirty minutes at 25°C. nine hours at 50°C, followed by eight
hours at 25°C. The solution was diluted with cold water (400 ml) and stirred
until the precipitated product turned granular (fifteen minutes). The crude
product was collected, washed with cold water, and dried. Crystallization from
Skellysolve B with charcoal treatment gave colorless crystals (6.65 g, 58%),
MP 149°C to 150°C. The product was recrystallized twice from Skellysolve B
to give (±)-6-chloro-5-cyclohexyl-1-indancarboxylic acid as colorless crystals,
MP 150.5°C to 152.5°C.
Therapeutic Function
Antiinflammatory, Antipyretic
Synthesis Reference(s)
Journal of Medicinal Chemistry, 15, p. 1297, 1972 DOI: 10.1021/jm00282a024
Check Digit Verification of cas no
The CAS Registry Mumber 34148-01-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,1,4 and 8 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34148-01:
(7*3)+(6*4)+(5*1)+(4*4)+(3*8)+(2*0)+(1*1)=91
91 % 10 = 1
So 34148-01-1 is a valid CAS Registry Number.
InChI:InChI=1/C16H19ClO2/c17-15-9-13-11(6-7-12(13)16(18)19)8-14(15)10-4-2-1-3-5-10/h8-10,12H,1-7H2,(H,18,19)
34148-01-1Relevant academic research and scientific papers
A NEW SYNTHESIS OF SOME NON-STEROIDAL ANTI-INFLAMMATORY AGENTS VIA CYANOPHOSPHATES
Hurusawa, Shinya,Nakamura, Shuji,Yagi, Sayoko,Kurihara, Takushi,Hamada, Yasumasa,Shioiri, Takayuki
, p. 1365 - 1372 (2007/10/02)
A simple and convenient procedure for the syntheses of some non-steroidal anti-inflammatory agents, ibuprofen, rac-naproxen, clidanac and loxoprofen, is described.
Derivatives of antiphlogistically effective carboxylic acids, their preparation and medicinal use
-
, (2008/06/13)
Compounds of Formula I STR1 wherein R1 is the residue of an antiphlogistically effective carboxylic acid of the formula R1 COOH, n is an integer 1, 2, or 3, and X is oxygen, sulfur, or optionally alkylated nitrogen have valuable antiinflammatory activity.
