341498-08-6 Usage
Description
N-succinimidyl 4-(2-pyridyldithio)pentanoate is a versatile chemical compound used in bioconjugation and labeling processes. It features a reactive succinimidyl ester group for amine labeling and a pyridyldithiol (SPDP) group for thiol labeling, making it a valuable tool for the development of protein conjugates and bioconjugates in scientific and medical research.
Uses
Used in Bioconjugation and Labeling Processes:
N-succinimidyl 4-(2-pyridyldithio)pentanoate is used as a crosslinker reagent for the modification of biomolecules such as proteins, antibodies, and peptides. Its dual reactivity allows for the formation of stable covalent bonds with amine and thiol groups, facilitating the creation of protein-protein conjugates and other bioconjugates for research and diagnostic applications.
Used in Protein-Protein Crosslinking:
In the field of protein engineering, N-succinimidyl 4-(2-pyridyldithio)pentanoate is employed as a crosslinking agent to connect two or more proteins together. This is particularly useful for studying protein interactions, creating artificial protein complexes, and developing novel biomaterials.
Used in Research and Diagnostic Applications:
N-succinimidyl 4-(2-pyridyldithio)pentanoate is utilized in various research and diagnostic applications, including the development of immunoassays, the synthesis of affinity reagents, and the modification of therapeutic agents. Its ability to label biomolecules with high specificity and stability makes it a valuable component in the advancement of life sciences and medicine.
Check Digit Verification of cas no
The CAS Registry Mumber 341498-08-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,1,4,9 and 8 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 341498-08:
(8*3)+(7*4)+(6*1)+(5*4)+(4*9)+(3*8)+(2*0)+(1*8)=146
146 % 10 = 6
So 341498-08-6 is a valid CAS Registry Number.
341498-08-6Relevant articles and documents
ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY
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Paragraph 00344, (2021/01/29)
The present disclosure relates to, among other things, antibody-drug conjugates comprising a STING agonist cyclic di-nucleotide conjugated to an antibody, preparation methods therefor, and uses therefor.
METHODS FOR PREPARATION OF CYTOTOXIC CONJUGATES OF MAYTANSINOIDS AND CELL BINDING AGENTS
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, (2016/08/03)
The Invention provides a method for producing a cytotoxic conjugate which comprises one or more maytansinoid molecules and a cell binding agent, said method consisting essentially of the single step of reacting one or more maytansinoid molecules containing a reactive ester with a cell binding agent.
Semisynthetic Maytansine analogues for the targeted treatment of cancer
Widdison, Wayne C.,Wilhelm, Sharon D.,Cavanagh, Emily E.,Whiteman, Kathleen R.,Leece, Barbara A.,Kovtun, Yelena,Goldmacher, Victor S.,Xie, Hongsheng,Steeves, Rita M.,Lutz, Robert J.,Zhao, Robert,Wang, Lintao,Bl?ttler, Walter A.,Chari, Ravi V. J.
, p. 4392 - 4408 (2007/10/03)
Maytansine, a highly cytotoxic natural product, failed as an anticancer agent in human clinical trials because of unacceptable systemic toxicity. The potent cell killing ability of maytansine can be used in a targeted delivery approach for the selective destruction of cancer cells. A series of new maytansinoids, bearing a disulfide or thiol substituent were synthesized. The chain length of the ester side chain and the degree of steric hindrance on the carbon atom bearing the thiol substituent were varied. Several of these maytansinoids were found to be even more potent in vitro than maytansine. The targeted delivery of these maytansinoids, using monoclonal antibodies, resulted in a high, specific killing of the targeted cells in vitro and remarkable antitumor activity in vivo.
