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Product FOB Price Min.Order Supply Ability Supplier
Celastrol cas 34157-83-0
Cas No: 34157-83-0
No Data 1 Gram 1000 Gram/Month Boc Sciences Contact Supplier
Cas No: 34157-83-0
No Data No Data Milligram /Day Chengdu Gelipu Biotechnology Co., Ltd. Contact Supplier
Cas No: 34157-83-0
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Cas No: 34157-83-0
USD $ 1300.0-1300.0 / Gram 10000 Gram 10 Metric Ton/Month Hebei yanxi chemical co.,LTD. Contact Supplier
Celastrol (Tripterin)
Cas No: 34157-83-0
No Data 1 Gram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
High quality Tripterin supplier in China
Cas No: 34157-83-0
No Data No Data No Data Simagchem Corporation Contact Supplier
Cas No: 34157-83-0
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
Cas No: 34157-83-0
No Data 1 Kilogram 1000 Kilogram/Month HENAN SUNLAKE ENTERPRISE CORPORATION Contact Supplier
Chinese Celastrol supplier suppliers manufacturer factory CAS 34157-83-0
Cas No: 34157-83-0
No Data No Data 1000 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
High quality Celastrol
Cas No: 34157-83-0
USD $ 1.0-1.0 / Kilogram 10 Kilogram 50 Metric Ton/Day Hubei Jusheng Technology Co., Ltd., Contact Supplier

34157-83-0 Usage


An antioxidant natural product which inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression. Used for clinical treatment for rheumatoid arthritis, was demonstrated to have antiangiogenic activity, and be

Pharmacological effects

  • Tripterine is a natural product with a variety of biological activity. It has a strong antioxidant effect, anti-cancer neovascularization effect as well as anti-rheumatoid effect. It is mainly isolated from the root bark of the celastraceae plant, Tripterygium wilfordii. It is one of the active ingredients contained in the rheumatoid-treatment drug Tripterygium tablet, Tripterygium Glycosides tablets and other preparations.
  • The major activity and pharmacological effects of Tripterine:
  • Cytotoxic activity. In vitro, it has non-specific cytotoxic activity against P388 and a group of human cancer cell lines.
  • Immune regulation. It could significantly inhibit the formation of hemolytic plaque cells in mouse spleen cells and significantly inhibit the mice delayed-type hypersensitivity.
  • Anti-inflammatory effect. At a dose of 0.5mg/kg, it could result in significant inhibition of the formation of rat cotton granuloma. At a dose of 0.1~1.0μg/mL, it could suppress the production of PGE2 induced by the yeast sugar; at a dose of 1.0μg/mL, it can inhibit the macrophage phagocytosis.
  • The anti-oxidation effect of tripterine is 15 times that of tocopherol with an IC50 of 7μM. Inhibit the peroxidation occurring inside and outside of the mitochondrial membrane, direct removing the free radicals.
  • Tripterine can extend the sleep time of mice triggered by the pentobarbital sodium.
  • Immunosuppressive effect: inhibit the spleen cell proliferation of mice induced by PHA, ConA and LPS, further inhibiting the lymphocyte proliferation.
  • It can inhibit the in vitro sperm fertilization capacity of guinea pig with the activity being significantly stronger than acetic acid gossypol.
  • Anti-arthritic effect, it will inhibit the activity of interleukin-1 of inside and outside the mouse intraperitoneal macrophages, inhibit the production of interleukin-2 by mouse spleen cells and lower the level of PGE2 produced by rabbit synovial cells.
Source: ChemicalBook Editorial.


It is an effective proteasome inhibitor. It has been confirmed that it is capable of inducing apoptosis of cancer cells through inhibiting proteasome activity.


An antioxidant onstrated to have antiangiogenic activity, and be inhibitory against mice tumor growth by a few recent studies.


ChEBI: A pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. otently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFkappaB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 muM).

Chemical Properties

Orange Red Solid

Biological Activity

Antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF- α -induced NF κ B activation. Also shown to inhibit topoisomerase II activity in vitro (IC 50 = 7.41 μ M).


antineoplastic, NO synthesis inhibitor, chaperone stimulant

34157-83-0 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (C0869)  Celastrol  ≥98% (HPLC), solid 34157-83-0 C0869-50MG 7,628.40CNY Detail
Sigma (C0869)  Celastrol  ≥98% (HPLC), solid 34157-83-0 C0869-10MG 1,904.76CNY Detail
TCI America (C2737)  Celastrol  >98.0%(HPLC) 34157-83-0 25mg 1,990.00CNY Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017


1.1 GHS Product identifier

Product name celastrol

1.2 Other means of identification

Product number -
Other names Tripterine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34157-83-0 SDS

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