3418-22-2

Basic information

• Product Name: 2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane
• Synonyms: 1,3-Dioxolane 2-[bromomethyl]-2-[4-bromophenyl]-; 1,3-Dioxolane, 2-bromomethyl-2-(4-bromophenyl)-
• CAS NO: 3418-22-2
• Molecular Formula: C₁₀H₁₀Br₂O₂
• Molecular Weight: 321.9932
• Mol File: 3418-22-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 351.6°C at 760 mmHg
• Flash Point: 143.4°C
• Density: 1.751g/cm³
• Vapor Pressure: 8.23E-05mmHg at 25°C
• Refractive Index: 1.583
• CAS DataBase Reference: 2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane(3418-22-2)
• EPA Substance Registry System: 2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane(3418-22-2)

Safety Data

• Hazardous Substances Data: 3418-22-2(Hazardous Substances Data)

Usage

General Description

2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane is a chemical compound with the molecular formula C9H8Br2O2. It is a dioxolane derivative that contains two bromine atoms and a benzene ring. 2-(bromomethyl)-2-(4-bromophenyl)-1,3-dioxolane is often used as a building block in organic synthesis and is commonly employed in the pharmaceutical industry for the production of various drugs and medications. It is also a versatile reagent in chemical reactions, particularly in the formation of carbon-carbon bonds. This chemical has potential applications in the field of medicinal chemistry, as well as in the development of new materials and compounds with specific properties.

Upstream product

• 107-21-1 ethylene glycol 
• 5391-88-8 1-(4-bromophenyl)ethanol 
• 99-90-1 para-bromoacetophenone 
• 99-73-0 para-bromophenacyl bromide 

Downstream Products

• 99-73-0 para-bromophenacyl bromide 
• 71053-90-2 1-{[2-(4-bromophenyl)-1,3-dioxolan-2-yl]methyl}-1H-imidazole hydrochloride 
• 60207-40-1 1-((2-(4-bromophenyl)-1,3-dioxolane-2-yl)methyl)-1H-1,2,4-triazole 

Relevant articles and documents

Propiconazole-like compound, and preparation method and application thereof

The invention discloses a propiconazole-like compound, and a preparation method and application thereof. The structural formula of the propiconazole-like compound is represented by formula (I)shown in the specification. In the formula (I), X is H, bromine

One-pot synthesis of α-bromoacetals of ketones from secondary alcohols and 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) in ethylene glycol

α-Bromoacetals of ketones were prepared from various secondary alcohols with 1,3-dibromo-5,5-dimethylhydantoin (DBDMH) and ethylene glycol through oxidation, bromination, and acetalization in one pot without the use of other catalysts under mild conditions. The effects of DBDMH, the solvent, and N-bromosuccinimide on the reaction were investigated. Under the optimal conditions, most α-bromoacetals of ketones were obtain in 90–98% yields.

Heme oxygenase inhibition by 1-Aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1- yl)ethanones and their derivatives

Previous studies by our research group have been concerned with the design of selective inhibitors of heme oxygenases (HO-1 and HO-2). The majority of these were based on a four-carbon linkage of an azole, usually an imidazole, and an aromatic moiety. In the present study, we designed and synthesized a series of inhibition candidates containing a shorter linkage between these groups, specifically, a series of 1-aryl-2-(1H-imidazol-1-yl/1H-1,2,4-triazol-1-yl) ethanones and their derivatives. As regards HO-1 inhibition, the aromatic moieties yielding best results were found to be halogen-substituted residues such as 3-bromophenyl, 4-bromophenyl, and 3,4-dichlorophenyl, or hydrocarbon residues such as 2-naphthyl, 4-biphenyl, 4-benzylphenyl, and 4-(2-phenethyl)phenyl. Among the imidazole-ketones, five (36-39, and 44) were found to be very potent (IC5050 in favor of HO-1. In the case of the azole-dioxolanes, two of them (80 and 85), each possessing a 2-naphthyl moiety, were found to be particularly potent and selective HO-1 inhibitors. Three non-carbonyl analogues (87, 89, and 91) of 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethanone were found to be good inhibitors of HO-1. For the first time in our studies, two azole-based inhibitors (37 and 39) were found to exhibit a modest selectivity index in favor of HO-2. The present study has revealed additional candidates based on inhibition of heme oxygenases for potentially useful pharmacological and therapeutic applications.