34192-82-0Relevant academic research and scientific papers
Continuous Flow Synthesis of Quinolines via a Scalable Tandem Photoisomerization-Cyclization Process
Di Filippo, Mara,Baumann, Marcus
, p. 6199 - 6211 (2020/08/26)
A continuous photochemical process is presented that renders a series of quinoline products via an alkene isomerization and cyclocondensation cascade. It is demonstrated that a high-power LED lamp generates the desired targets with higher productivity and efficiency than a medium-pressure Hg-lamp. The scope of this tandem process is established and allows for the generation of various substituted quinolines in high yields and with throughputs of greater than one gram per hour. Finally, this effective flow process is coupled with a telescoped hydrogenation reaction to render a series of tetrahydroquinolines including the antimalarial natural product galipinine.
A practical synthesis of 2-aroylindoles from N-(2-formylphenyl)trifluoro- acetamides in PEG-400
Zhao, Yu,Li, Deyao,Zhao, Liwen,Zhang, Jiancun
experimental part, p. 873 - 880 (2011/04/26)
A one-pot and environmentally benign approach to the synthesis of highly functionalized 3-unsubstituted 2-aroylindoles is described. Moderate to good yields were obtained through the reaction of easily accessible N-(2-formylphenyl)trifluoroacetamides and
Palladium-catalyzed domino C,N-coupling/carbonylation/suzuki coupling reaction: An efficient synthesis of 2-aroyl-/heteroaroylindoles
Arthuls, Martin,Pontikis, Renee,Florent, Jean-Claude
supporting information; experimental part, p. 4608 - 4611 (2009/12/09)
A convenient one-pot synthesis of 2-aroylindoles using a domino palladium-catalyzed C,N-coupllng/carbonylatlon/C,C-coupling sequence Is described. The reaction Involved easily prepared 2-gem-dibromovinylanilines and boronic acids under carbon monoxide. Op
Synthesis of 2-Acyl- and 2-Benzoylindoles
Mali, Raghao S.,Tilve, Santosh G.,Desai, Vidya G.
, p. 150 - 158 (2007/10/03)
2-Nitrobenzaldehydes (3a-c) on reaction with phosphoranes (4a and 4b), and triphenyl phosphine in refluxing diphenylether provide 2-acylindoles (6a-c) and 2-benzoylindoles (6d-f). Alternatively 2-nitrobenzaldehydes (3a-c) on reaction with phosphoranes (4a and 4b) give nitroketones (5a-f) which on refluxing with triphenyl phosphine in refluxing diphenyl ether furnish 2-acyl- and 2-benzoylindoles (6a-f).
