341998-52-5

Upstream product

• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 290333-08-3 N-tosyl-3-acetyl-4-benzyloxy-7-bromoindole 
• 1761-61-1 5-bromosalicyclaldehyde 
• 100-39-0 benzyl bromide 
• 290333-13-0 ethyl 2-azido-3-(2-benzyloxy-5-bromophenyl)propenoate 
• 290333-14-1 ethyl 4-(benzyloxy)-7-bromo-1H-indole-2-carboxylate 
• 290333-15-2 4-benzyloxy-7-bromoindole-2-carboxylic acid 
• 290333-12-9 3-acetyl-4-benzyloxy-7-bromoindole 
• 290333-11-8 4-benzyloxy-7-bromoindole 
• 121124-94-5 2-benzyloxy-5-bromobenzaldehyde 

Downstream Products

• 290333-16-3 4-benzyloxy-7-bromo-3-[(2-amino)pyrimidin-4-yl]indole 

Relevant academic research and scientific papers

Synthesis of the indole alkaloids meridianins from the tunicate Aplidium meridianum

The marine natural products meridianins A and C-E have been synthesized for the first time starting from the appropriate N-tosyl-3-acetylindole. A facile two-step conversion of N-tosyl-3-acetylindoles to the corresponding meridianins by treatment with dimethylformamide dimethylacetal and further cyclization of the resulting enaminone with aminoguanidine is described. This method has also been applied for the preparation of the 3-[(2-amino)pyrimidin-4-yl]-7-azaindole.

Synthetic studies towards the 2-aminopyrimidine alkaloids variolins and meridianins from marine origin

A nine-step synthesis of 9-amino-4-methoxypyrido[3',2':4,5]pyrrolo[1,2- c]pyrimidine, a tricyclic ring system present in the marine alkaloids variolins is described. The natural marine products meridianins C-E have been synthesized for the first time starting from N-protected 3-acylindoles. (C) 2000 Elsevier Science Ltd.