342026-17-9

Usage

Uses

Used in Pharmaceutical Synthesis:
ETHYL-3-ISOPROPYL PYRAZOLE-4-CARBOXYLATE is used as a key intermediate in the synthesis of various pharmaceuticals for its potential to modulate biological processes. Its unique structure allows for the development of new drugs with specific therapeutic effects.
Used in Agrochemical Synthesis:
In the agrochemical industry, ETHYL-3-ISOPROPYL PYRAZOLE-4-CARBOXYLATE is used as a precursor in the development of insecticides, fungicides, and herbicides. Its bioactivity makes it a promising candidate for creating effective crop protection products.
Used in Agricultural Applications:
ETHYL-3-ISOPROPYL PYRAZOLE-4-CARBOXYLATE is used as a bioactive compound in agricultural fields for its potential as an insecticide, fungicide, and herbicide. It aids in the protection of crops from pests, diseases, and unwanted plant growth, thereby enhancing crop yield and quality.
Used in Research and Development:
ETHYL-3-ISOPROPYL PYRAZOLE-4-CARBOXYLATE is utilized in research and development for its potential to contribute to the creation of innovative pharmaceuticals and agrochemicals. Its unique properties and ability to modulate biological processes make it a valuable compound for further exploration and synthesis of new products.

InChI:InChI=1/C9H14N2O2/c1-4-13-9(12)7-5-10-11-8(7)6(2)3/h5-6H,4H2,1-3H3,(H,10,11)

Upstream product

• 623-47-2 propynoic acid ethyl ester 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 72898-73-8 ethyl 2-(ethoxymethylene)-4-methyl-3-oxopentanoate 

Downstream Products

• 1003578-25-3 ethyl 3-isopropyl-1-phenyl-1H-pyrazole-4-carboxylate 
• 1609564-88-6 3-isopropyl-1-(3-methoxybenzyl)-1H-pyrazole-4-carboxylic acid 
• 1609564-92-2 3-isopropyl-1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-1H-pyrazole-4-carboxamide 
• 1609564-98-8 3-isopropyl-1-(3-methoxybenzyl)-N-methyl-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-1H-pyrazole-4-carboxamide 
• 1609565-01-6 N-((3-isopropyl-1-(3-methoxybenzyl)-1H-pyrazol-4-yl)methyl)-4-methyl-3-(morpholinosulfonyl)aniline 
• 628332-42-3 2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde 

Relevant academic research and scientific papers

FARNESOID X RECEPTOR ANTAGONISTS

Provided herein are Farnesoid X receptor (FXR) antagonists, methods of antagonizing FXR, and methods of treating metabolic disease using the antagonists herein.

Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor

Farnesoid X receptor (FXR, NRIH4) plays a major role in the control of cholesterol metabolism. This suggests that antagonizing the transcriptional activity of FXR is a potential means to treat cholestasis and related metabolic disorders. Here we describe the synthesis, biological evaluation, and structure-activity relationship (SAR) studies of trisubstituted-pyrazol carboxamides as novel and potent FXR antagonists. One of these novel FXR antagonists, 4j has an IC50 of 7.5 nM in an FXR binding assay and 468.5 nM in a cell-based FXR antagonistic assay. Compound 4j has no detectable FXR agonistic activity or cytotoxicity. Notably, 4j is the most potent FXR antagonist identified to date; it has a promising in vitro profile and could serve as an excellent chemical tool to elucidate the biological function of FXR.

Solid-phase synthesis of amino acid derived N-unsubstituted pyrazoles via sydnones

A new method to synthesize N-unsubstituted pyrazoles on a solid support is described. The solid support acts as a protecting group for the amino acid. N-Protected amino acid is N-nitrosated, and the subsequent treatment with acetic anhydride in a microwav

AMIDE COMPOUNDS

The present invention provides compounds represented by the formula (Ia) the formula (Ib) the formula (Ic) and the formula (Id) wherein each symbol is as defined in the specification. According to the present invention, these compounds have a DGAT inhibit