34203-08-2Relevant academic research and scientific papers
Combined Scaffold Evaluation and Systems-Level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes
Rodriguez, Kevin X.,Howe, Erin N.,Bacher, Emily P.,Burnette, Miranda,Meloche, Jennifer L.,Meisel, Jayda,Schnepp, Patricia,Tan, Xuejuan,Chang, Mayland,Zartman, Jeremiah,Zhang, Siyuan,Ashfeld, Brandon L.
, p. 1653 - 1661 (2019/07/09)
With evolutionary drug resistance impacting efforts to treat disease, the need for small molecules that exhibit novel molecular mechanisms of action is paramount. In this study, we combined scaffold-directed synthesis with a hybrid experimental and transc
Palladium/copper-catalyzed oxidative C-H alkenylation/N-dealkylative carbonylation of tertiary anilines
Shi, Renyi,Lu, Lijun,Zhang, Hua,Chen, Borui,Sha, Yuchen,Liu, Chao,Lei, Aiwen
supporting information, p. 10582 - 10585 (2013/10/21)
C-H/C-N activation: The first palladium/copper-catalyzed aerobic oxidative C-H alkenylation/N-dealkylative carbonylation of tertiary anilines has been developed. Various functional groups were tolerated and acrylic ester could also be suitable substrates. This transformation provided efficient and straightforward synthesis of biologically active 3-methyleneindolin-2-one derivatives from cheap and simple substrates. Copyright
