342032-51-3Relevant academic research and scientific papers
Synthesis, spectral, thermal, kinetic and antibacterial studies of transition metal complexes with benzimidazolyl-2-hydrazones of o-hydroxyacetophenone, o-hydroxybenzophenone and o-vanillin
Mohapatra, Ranjan K.,Das, Pradeep K.,El-ajaily, Marei M.,Mishra, Umakanta,Dash, Dhruba C.
, p. 437 - 450 (2018)
A novel series of Schiff base metal complexes of the type [M(L)2].nH2O, where L= 2-(α-methylsalicylidenehydrazino) benzimidazole (L1), 2-(α-phenylsalicylidenehydrazino)benzimidazole (L2), 2-(o-vanillinidenehydrazino)benzimidazole (L3
New 1H-benzimidazole-2-yl hydrazones with combined antiparasitic and antioxidant activity
Argirova, Maria A.,Georgieva, Miglena K.,Hristova-Avakumova, Nadya G.,Vuchev, Dimitar I.,Popova-Daskalova, Galya V.,Anichina, Kameliya K.,Yancheva, Denitsa Y.
, p. 39848 - 39868 (2021/12/31)
Parasitic infections, caused mainly by the speciesTrichinella spiralis(T. spiralis), are widespread around the world and lead to morbidity and mortality in the population. Meanwhile, some studies have showed that these parasites induce oxidative stress in the infected host. With the aim of developing a class of compounds combining anthelmintic with antioxidant properties, a series of new benzimidazolyl-2-hydrazones5a-l, bearing hydroxyl- and methoxy-groups, were synthesized. The anthelmintic activity on encapsulatedT. spiraliswas studiedin vitrothus indicating that all hydrazones were more active than the clinically used anthelmintic drugs albendazole and ivermectin.5band5dkilled the total parasitic larvae (100% effectiveness) after 24 hours incubation period at 37 °C in both concentrations (50 and 100 μg ml?1). The antioxidant activity of the target compounds was elucidatedin vitroagainst stable free radicals DPPH and ABTS as well as iron induced oxidative damage in model systems containing biologically relevant molecules lecithin and deoxyribose. The two 2,3- and 3,4-dihydroxy hydrazones5band5dwere the most effective radical scavengers in all studied systems. DFT calculations were applied to calculate the reaction enthalpies in polar and nonpolar medium and estimate the preferred mechanism of antioxidant activity. The relative radical scavenging ability of compounds5a-lshowed a good correlation to the experimentally observed trends. It was found that the studied compounds are capable to react with various free radicals - ˙OCH3, ˙OOH and ˙OOCH3, through several possible reaction pathways - HAT in nonpolar medium, SPLET in polar medium and RAF in both media.
Design, spectral and antibacterial investigations of some mixed ligand metal complexes
Biswal, Susanta K.,Mohapatra, Ranjan K.,Pradhan, Debapriya
, p. 339 - 343 (2020/07/03)
A novel series of mixed ligand Co(II), Cu(II), and Zn(II) complexes of the type [M(L1)(L2) Cl].2H2O, where HL1= 2-(o-vanillinidenehydrazino)benzimidazole (primary ligand) and L2 = 2, 2′-bipyridine (secondary ligand) have been synthesized and in
