342045-15-2

Basic information

• Product Name: N-{2-tert-butyl-5-nitrophenyl}acetamide
• Synonyms: N-{2-tert-butyl-5-nitrophenyl}acetamide
• CAS NO: 342045-15-2
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.26704
• Mol File: 342045-15-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-{2-tert-butyl-5-nitrophenyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-{2-tert-butyl-5-nitrophenyl}acetamide(342045-15-2)
• EPA Substance Registry System: N-{2-tert-butyl-5-nitrophenyl}acetamide(342045-15-2)

Safety Data

• Hazardous Substances Data: 342045-15-2(Hazardous Substances Data)

Upstream product

• 7402-70-2 N-(2-tert-butylphenyl)acetamide 
• 6310-21-0 2-(1,1-dimethylethyl)-benzenamine 
• 103392-84-3 2-tert-Butyl-5-nitro-phenylamine 
• 75-36-5 acetyl chloride 

Downstream Products

• 453562-68-0 1-(3,3-dimethyl-6-nitro-2,3-dihydro-indol-1-yl)-ethanone 
• 103392-84-3 2-tert-Butyl-5-nitro-phenylamine 
• 923547-38-0 N-(5-amino-2-tert-butyl-phenyl)-acetamide 

Relevant articles and documents

Catalytic C(sp3)?H Arylation of Free Primary Amines with an exo Directing Group Generated In Situ

Herein, we report the palladium-catalyzed direct arylation of unactivated aliphatic C?H bonds in free primary amines. This method takes advantage of an exo-imine-type directing group (DG) that can be generated and removed in situ. A range of unprotected aliphatic amines are suitable substrates, undergoing site-selective arylation at the γ-position. Methyl as well as cyclic and acyclic methylene groups can be activated. Furthermore, when aniline-derived substrates were used, preliminary success with δ-C?H arylation was achieved. The feasibility of using the DG component in a catalytic fashion was also demonstrated.

Palladium-catalyzed amidation of unactivated c(sp3)-h bonds: From anilines to indolines

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