3422-91-1Relevant academic research and scientific papers
COMPOUND OR SALT THEREOF, NATURAL KILLER T CELL ACTIVATOR, AND PHARMACEUTICAL COMPOSITION
-
Paragraph 0088-0090; 0153, (2020/07/16)
The invention provides a compound or a salt thereof capable of activating natural killer T cell, a natural killer T cell activating agent containing such a compound or a salt thereof, and a pharmaceutical composition. The compound of the invention is a co
Synthesis of biotin and fluorescein labeled (-)-lentiginosine
Cordero, Franca M.,Vurchio, Carolina,Macchi, Beatrice,Minutolo, Antonella,Brandi, Alberto
, p. 215 - 227 (2014/06/09)
The important proapoptotic activity of (-)-lentiginosine, the enantiomer of a natural glycosidase inhibitor, associated with its low cytotoxicity, suggests the study of the unknown receptor responsible for the triggering of the proapoptotic cascade. To th
ALIPHATIC PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS WITH BETA AGONIST ACTIVITY
-
Page/Page column 55, (2010/11/29)
The present invention provides sodium channel blockers possessing beta-adrenergic receptor agonist activity.
Benzyl and tert-butyl carbamate derivatives of 1,ω-amino acids as simple yet efficient gelators
D'Ale?o, Anthony,Pozzo, Jean-Luc,Heuzé, Karine,V?gtle, Fritz,Fages, Frédéric
, p. 7482 - 7488 (2008/02/05)
We report the synthesis and a study of the gelation properties of a series of N-protected long-chain amino acids. Especially, benzyl and tert-butyl carbamate derivatives of 11-aminoundecanoic acid in their deprotonated form can gelate polar organic solvents and water at very low concentration (less than 5 mM). This is explained by the contribution of multiple forces-H-bond, van der Waals and ionic interactions-in the gel aggregate formation and stabilization, which is confirmed by the experimental data. Among the series of compounds investigated, only a dimer of 11-aminoundecanoic acid is capable of gelating toluene, which stems from the increased number of hydrogen bonding sites in the main aliphatic chain.
Substituted N-carboxyalkylpeptidyl derivatives as antidegenerative agents
-
, (2008/06/13)
Novel N-carboxyalkylpeptidyl compounds represented by the formula which are found to be useful inhibitors of matrix metalloendoproteinases which degrade major components of articular cartilage and basement membranes causing degenerative diseases such as a
Synthetic Analogues of Low-Molecular-Weight Acyl-polyamine Spider Toxins
Fiedler, Wolfgang J.,Guggisberg, Armin,Hesse, Manfred
, p. 1167 - 1181 (2007/10/02)
Low-molecular-weight spider and wasp toxins are selective inhibitors of glutamate receptors of the central nervous system and consist of a polyamine backbone and one or several carboxylic acids and/or amino acids linked by a peptide-like bond.The syntheses of twelve analogues of spider and wasp toxins are described (10a-c, 15a-c, 20a-c, 25a-c) having the general structure of acyl, arylacyl, or heteroarylacyl -> DL-alanyl -> ω-aminoacyl -> N1-spermidine, with variation in the acyl and the ω-aminoacyl part.
Glucosamine derivatives
-
, (2008/06/13)
Compounds of the following formula and their physiologically acceptable salts are novel and have excellent immunostimulatory activity: STR1
