34220-09-2Relevant academic research and scientific papers
Studies on the Cu(I)-catalyzed regioselective anti-carbometallation of secondary terminal propargylic alcohols
Lu, Zhan,Ma, Shengming
, p. 2655 - 2660 (2007/10/03)
A highly regioselective Cu(I)-catalyzed anti-carbometallation of secondary terminal propargylic alcohols with 1° alkyl or aryl Grignard reagents affording 2-substituted allylic alcohols was developed. By using this method, optically active allylic alcohols can be prepared from the optically active propargylic alcohols without obvious loss of the enantiopurity. The cyclic organometallic intermediate formed may undergo an iodination or a Pd(0)-catalyzed coupling reaction to afford stereo-defined allylic alcohols.
