3423-46-9

Basic information

• Product Name: ethyl 2-(4-cyanopyridin-3-yl)acetate
• Synonyms: ethyl 2-(4-cyanopyridin-3-yl)acetate
• CAS NO: 3423-46-9
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 3423-46-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 130 °C(Press: 1.7 Torr)
• Appearance: /
• Density: 1.17±0.1 g/cm3(Predicted)
• PKA: 1.46±0.18(Predicted)
• CAS DataBase Reference: ethyl 2-(4-cyanopyridin-3-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(4-cyanopyridin-3-yl)acetate(3423-46-9)
• EPA Substance Registry System: ethyl 2-(4-cyanopyridin-3-yl)acetate(3423-46-9)

Safety Data

• Hazardous Substances Data: 3423-46-9(Hazardous Substances Data)

Upstream product

• 3423-47-0 3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate 
• 75-03-6 ethyl iodide 
• 1609558-94-2 C₁₃H₁₄N₂O₄ 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 1365762-73-7 3-(2-ethoxy-2-oxoethyl)pyridine-1-oxide ethyl iodide 

Downstream Products

• 58553-56-3 3,4-dihydro-2,6-naphthyridin-1(2H)-one 
• 1365762-79-3 3-(2-hydroxyethyl)-N-(4-methoxybenzyl)isonicotinamide 
• 1365762-81-7 2-(4-methoxybenzyl)-3,4-dihydro-2,6-naphthyridin-1(2H)-one 
• 1609558-88-4 C₁₁H₁₁N₃O₂ 
• 52463-33-9 3-chloro-2,6-naphthyridine 

Relevant articles and documents

METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS

The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

A versatile annulation route to primary-amino-substituted naphthyridine esters

A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyano-pyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of -primary-amino-substituted 7-azaquinoxaline was also described. Georg Thieme Verlag Stuttgart · New York.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.