3423-46-9

Upstream product

• 3423-47-0 3-(2-ethoxy-2-oxoethyl)pyridin-1-ium-1-olate 
• 75-03-6 ethyl iodide 
• 1609558-94-2 C₁₃H₁₄N₂O₄ 
• 39931-77-6 pyridin-3-yl-acetic acid ethyl ester 
• 1365762-73-7 3-(2-ethoxy-2-oxoethyl)pyridine-1-oxide ethyl iodide 

Downstream Products

• 58553-56-3 3,4-dihydro-2,6-naphthyridin-1(2H)-one 
• 1365762-79-3 3-(2-hydroxyethyl)-N-(4-methoxybenzyl)isonicotinamide 
• 1365762-81-7 2-(4-methoxybenzyl)-3,4-dihydro-2,6-naphthyridin-1(2H)-one 
• 1609558-88-4 C₁₁H₁₁N₃O₂ 
• 52463-33-9 3-chloro-2,6-naphthyridine 

Relevant academic research and scientific papers

METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS

The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.

Synthesis of two 'heteroaromatic rings of the future' for applications in medicinal chemistry

In a computational study, the 1H-pyrazolo[3,4-c]pyridin-5-ol and 2,6-naphthyridin-3-ol heterocycles were identified as unknown heteroaromatic ring systems of potential value for medicinal chemistry. Here we report robust and concise synthetic protocols that provide access to these two scaffolds on a multigram scale.

A versatile annulation route to primary-amino-substituted naphthyridine esters

A straightforward four-step synthesis of primary-amino-substituted naphthyridine esters from commercially available cyano-pyridines was described. The route makes use of a condensation reaction between pyridinyl acetates with N,N-dimethylformamide dimethylacetal (DMF-DMA) to form ortho-cyano vinylogous carbamates. These intermediates can undergo facile cyclization with ammonium acetate in acetic acid to generate the corresponding naphthyridine esters in good synthetic yields. The synthesis of -primary-amino-substituted 7-azaquinoxaline was also described. Georg Thieme Verlag Stuttgart · New York.

17a-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.

17α-HYDROXYLASE/C17,20-LYASE INHIBITORS

The present invention provides compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, R2, R3, R4, R5, R6, A and n are as defined herein. A deuteriated derivative of the compound of Formula (I) is also provided.