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34231-49-7

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34231-49-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 34231-49-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,3 and 1 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 34231-49:
(7*3)+(6*4)+(5*2)+(4*3)+(3*1)+(2*4)+(1*9)=87
87 % 10 = 7
So 34231-49-7 is a valid CAS Registry Number.

34231-49-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-(N,N-Dimethylaminocarbonyl)benzoic acid

1.2 Other means of identification

Product number -
Other names 4-(N,N-Dimethylaminocarbonyl)benzoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:34231-49-7 SDS

34231-49-7Relevant articles and documents

KCNT1 INHIBITORS AND METHODS OF USE

-

, (2020/11/23)

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

Novel Human Aminopeptidase N Inhibitors: Discovery and Optimization of Subsite Binding Interactions

Lee, Jisook,Vinh, Natalie B.,Drinkwater, Nyssa,Yang, Wei,Kannan Sivaraman, Komagal,Schembri, Luke S.,Gazdik, Michelle,Grin, Peter M.,Butler, Georgina S.,Overall, Christopher M.,Charman, Susan A.,McGowan, Sheena,Scammells, Peter J.

, p. 7185 - 7209 (2019/08/28)

Aminopeptidase N (APN/CD13) is a zinc-dependent M1 aminopeptidase that contributes to cancer progression by promoting angiogenesis, metastasis, and tumor invasion. We have previously identified hydroxamic acid-containing analogues that are potent inhibitors of the APN homologue from the malarial parasite Plasmodium falciparum M1 aminopeptidase (PfA-M1). Herein, we describe the rationale that underpins the repurposing of PfA-M1 inhibitors as novel APN inhibitors. A series of novel hydroxamic acid analogues were developed using a structure-based design approach and evaluated their inhibition activities against APN. N-(2-(Hydroxyamino)-2-oxo-1-(3′,4′,5′-trifluoro-[1,1′-biphenyl]-4-yl)ethyl)-4-(methylsulfonamido)benzamide (6ad) proved to be an extremely potent inhibitor of APN activity in vitro, selective against other zinc-dependent enzymes such as matrix metalloproteases, and possessed limited cytotoxicity against Ad293 cells and favorable physicochemical and metabolic stability properties. The combined results indicate that compound 6ad may be a useful lead for the development of anticancer agents.

Acidity of benzoic acids bearing the (CO)5Cr=CN(CH 3)2 group

Parik, Patrik,Kulhanek, Jiri,Ludwig, Miroslav,Wagner, Roman,Rotrekl, Ivan,Drahonovsky, Dusan,Meca, Ludek,Smidkova, Marketa,Tobrman, Tomas,Dvorak, Dalimil

experimental part, p. 4135 - 4138 (2011/01/03)

Benzoic acids 2a and 2b, bearing the (CO)5Cr=CN(CH 3)2 group in the p- and m-position, and the corresponding benzoic acids 2c and 2d, in which the rotation of the aminocarbene moiety was blocked by the presence of a methyl group, were prepared together with the corresponding N,N-dimethylamido acids 3a-d. The measurement of pKa values in EtOH and DMF revealed that the (CO)5Cr=CN(CH 3)2 group is a very weak electron acceptor (δp = 0; δm = 0.14). The restriction of the rotation of the aminocarbene moiety did not significantly influence its electronic properties. The obtained results are in accordance with earlier findings that the relatively strong acidity of carbene complexes bearing hydrogens at the ±-position to the carbene atom is due to the resonance stabilization of the anion.

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