342376-58-3

Upstream product

• 81477-94-3 N-(diphenylmethylene)glycine tert-butyl ester 
• 94594-90-8 (2R)-bornane-10,2-sultam 
• 434331-68-7 2-(benzhydrylidene-amino)-pent-2-enedioic acid 1-tert-butyl ester 5-methyl ester 

Downstream Products

• 342376-60-7 (Z)-(R)-2-(Benzhydrylidene-amino)-5-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-4-methyl-5-oxo-pent-2-enoic acid tert-butyl ester 
• 342376-63-0 (Z)-(R)-2-(Benzhydrylidene-amino)-5-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-4-(4-nitro-benzyl)-5-oxo-pent-2-enoic acid tert-butyl ester 
• 342376-62-9 (Z)-(R)-2-(Benzhydrylidene-amino)-4-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]decane-4-carbonyl)-hex-2-enedioic acid 1-tert-butyl ester 6-ethyl ester 
• 342376-61-8 (Z)-(R)-2-(Benzhydrylidene-amino)-4-benzyl-5-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-5-oxo-pent-2-enoic acid tert-butyl ester 

Relevant academic research and scientific papers

Conformationally restricted glutamic acid derivatives: Asymmetric synthesis of 4-substituted 4,5-dihydro-3(2H)-pyridazinones

The synthesis of optically pure 4,5-dihydro-3(2H)-pyridazinones substituted at C-4, which can be considered conformationally restricted cyclic Glu derivatives, has been accomplished by the asymmetric γ-alkylation of α,β-unsaturated glutamyl sultams under PTC conditions followed by reaction with hydrazines.