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Usage

Carboxylic acid derivative

It is a compound derived from carboxylic acids, which are known for their acidic properties and functional groups (-COOH).

Class

2-hydroxy carboxylic acids This classification is based on the presence of a hydroxyl (-OH) group and a carboxylic acid (-COOH) group in the molecule.

Pharmaceutical industry use

Building block for drug synthesis 2-(1-hydroxycyclohexyl)propanoic acid serves as a key intermediate in the production of various drugs and pharmaceutical intermediates.

Manufacturing applications

Fragrances, flavors, and specialty chemicals The compound is used in the production of fragrances, flavors, and other specialty chemicals due to its unique properties.

Cosmetic industry potential

Moisturizing and antioxidant properties 2-(1-hydroxycyclohexyl)propanoic acid has potential applications in the cosmetic industry because of its ability to retain moisture and neutralize harmful free radicals.

Diverse industrial applications

The compound is an important intermediate in the production of a wide range of products, making it a versatile and valuable chemical in various industries.

Upstream product

• 108-94-1 cyclohexanone 
• 802294-64-0 propionic acid 
• 66730-60-7 C₃H₄O₂^(2-)*2Li⁽¹⁺⁾ 
• 39922-60-6 ethyl 2-(1-hydroxycyclohexyl)propionate 

Downstream Products

• 1003-64-1 ethylidenecyclohexane 
• 77124-22-2 2-cyclohexylidenepropanoic acid 
• 2205-24-5 2-cyclohex-1-enyl-propionic acid 

Relevant academic research and scientific papers

Irreversible aldolization of ketones with bisdicyclohexylboron enediolates

Unlike the reported reversible addition of ketone enolborinates to ketones, the aldolization of ketones with bisboron enediolates derived from carboxylic acids proceeds without difficulty. A variety of α,β,β-trisubstituted-β-hydroxy acids have been thus s

SYNTHETIS OF CYCLIC AND ACYCLIC β,γ-UNSATURATED CARBOXYLIC ACIDS VIA AN E1-TYPE IONIZATION/ELIMINATION OF β-LACTONES

Cyclic and acyclic ketones were converted in three steps into 3-alkenoic acids, bearing a variety of substituents in the α-position.The sequence, involving ionization/elimination of a β-lactone, affords high yields of pure products uncontaminated with conjugated isomers.Support for an E1-type mechanism is also provided.

AN EFFICIENT, HIGHLY REGIOSELECTIVE SYNTHESIS OF SUBSTITUTED (1-CYCLOHEXENYL) ACETIC ACID DERIVATIVES VIA IONIZATION/ELIMINATION OF β-LACTONES

When treated with magnesium bromide, spiro β-lactones undergo an ionization/elimination reaction to afford cyclohexenyl acetic acid derivatives in high yield and isomeric purity.

CHIRAL PROPIONATE ENOLATE EQUIVALENT FOR STEREOSELECTIVE ADDITIONS TO SYMMETRICAL KETONES

The copper enolate derived from (n5-C5H5)Fe(CO)(PPh3)COCH2CH3 reacts stereoselectively with symmetrical ketones to generate RR,SS-α-methyl-β-hydroxy acyl complexes which on decomplexation liberate the corresponding β-hydroxy acids.

Reaction de Reformatsky a froid avec des α-bromoesters-acetals. I. Une methode generale pour la synthese des β-hydroxyacides a partir des α-bromoesters de tetrahydropyrannyle (Note de laboratoire)

The readily accessible tetrahydropyranyl esters of α-bromoacids can be used in the Reformatsky reaction for the preparation of β-hydroxyacids.The reaction is generally carried out in cold tetrahydrofuran.The β-hydroxyacids can be easily obtained by stirring the cold solution of their tetrahydropyranyl esters with dilute hydrochloric acid.